低分子肝素钙联合丁苯酞注射液治疗进展性脑梗死的效果及对患者NIHSS评分与生活质量的影响

Effect of Low Molecular Weight Heparin Calcium Combined with Butylphthalide Injection in the Treatment of Progressive Cerebral Infarction and Its Effect on NIHSS Score and Quality of Life of Patients

目的:探讨低分子肝素钙联合丁苯酞注射液治疗进展性脑梗死的效果及对患者NIHSS评分与生活质量的影响。方法:选取2018年8月-2019年8月本院收治的112例进展性脑梗死患者进行研究。将患者随机分为对照组和研究组,各56例。对照组采用低分子肝素钙注射液治疗,研究组采用低分子肝素钙注射液联合丁苯酞氯化钠注射液治疗。观察两组的临床疗效,比较两组治疗前后的NIHSS评分、BI评分、内皮功能、炎症因子及血液流变学指标。结果:研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组NIHSS评分低于对照组,BI评分高于对照组,差异均有统计学意义(P<0.05)。治疗后,研究组TNF-α、hs-CRP及ET水平均低于对照组,NO水平高于对照组,差异均有统计学意义(P<0.05)。治疗后,研究组的HBV、LBV及HGX均低于对照组,差异均有统计学意义(P<0.05)。结论:使用低分子肝素钙联合丁苯酞注射液治疗进展性脑梗死患者的效果明显,可以改善机体内皮功能和血液流变学,降低炎性因子,降低神经缺损程度,提升患者生活质量,值得应用。

Objective:To investigate the effect of Low Molecular Weight Heparin Calcium combined with Butylphthalide Injection in patients with progressive cerebral infarction and its effect on NIHSS score and quality of life.Method:A total of 112 patients with progressive cerebral infarction admitted to our hospital from August 2018 to August 2019 were selected for this study.The patients were randomly divided into control group and study group,56 cases in each group.The control group was treated with Low Molecular Weight Heparin Calcium Injection,and the research group was treated with Low Molecular Weight Heparin Calcium Injection combined with Butylphthalide Sodium Chloride Injection.The clinical efficacy of the two groups was observed,NIHSS score,BI score,endothelial function,inflammatory factors and hemorheology indexes were compared between the two groups before and after treatment.Result:The total effective rate of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,the NIHSS score of the study group was lower than that of the control group,and the BI score of the study group was higher than that of the control group,the differences were statistically significant(P<0.05).After treatment,the levels of TNF-α,hs-CRP and ET in the study group were lower than those in the control group,and the level of NO was higher than that in the control group,the differences were statistically significant(P<0.05).After treatment,HBV,LBV and HGX in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Low Molecular Weight Heparin Calcium combined with Butylphthalide Injection in the treatment of patients with progressive cerebral infarction has obvious effects,can improve the body’s endothelial function and hemorheology,reduce inflammatory factors,reduce the degree of nerve defect,improve the quality of life of patients,worthy of application.