注射用艾司奥美拉唑钠联合内镜下注射治疗对急性消化性溃疡出血患者的影响

Influence of Esomeprazole Sodium Injection Combined with Endoscopic Injection in Patients with Acute Peptic Ulcer Hemorrhage

目的:探讨注射用艾司奥美拉唑钠联合内镜下注射治疗对于急性消化性溃疡出血的影响。方法:选择本院2018年11月-2020年3月进行治疗的94例急性消化性溃疡出血患者。根据随机数字表法分为对照组和观察组,每组47例。两组患者均实施常规对症治疗,禁食,维持水电解质平衡等,对于失血过多的患者,给予输血治疗。对照组采用内镜下注射治疗。观察组在对照组的基础上加用注射用艾司奥美拉唑钠。比较两组疗效、出血停止时间、呕血停止时间、黑便停止时间、出血量、不良反应发生情况及干预前后的血红蛋白水平、凝血指标、hs-CRP、IL-6、COR水平。结果:观察组总有效率为95.74%高于对照组的78.72%,差异有统计学意义(P<0.05)。观察组出血、呕血、黑便停止时间和出血量均少于对照组,差异均有统计学意义(P<0.05)。干预前,两组血红蛋白、PT、APTT、PLT、纤维蛋白原、D-二聚体、HCT、hs-CRP、IL-6、COR水平比较,差异均无统计学意义(P>0.05)。干预后,两组PT、APTT、纤维蛋白原、D-二聚体、hs-CRP、IL-6、COR水平均低于干预前,血红蛋白、PLT、HCT水平高于干预前,差异均有统计学意义(P<0.05)。干预后,观察组PT、APTT、纤维蛋白原、D-二聚体、hs-CRP、IL-6、COR水平均低于对照组,血红蛋白、PLT、HCT水平高于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率为4.26%低于对照组的21.28%,差异有统计学意义(P<0.05)。结论:对于急性消化性溃疡出血的患者而言,通过注射用艾司奥美拉唑钠联合内镜下注射治疗,可以改善患者的临床症状,快速止血,减少出血量,改善血红蛋白水平和凝血指标,改善hs-CRP、IL-6、COR水平,降低不良反应发生率,应用价值较高。

Objective:To investigate the influence of Esomeprazole Sodium Injection combined with endoscopic injection in patients with acute peptic ulcer hemorrhage.Method:A total of 94 patients with acute peptic ulcer hemorrhage who received treatment in our hospital from November 2018 to March 2020 were selected,and they were divided into control group and observation group according to random number table method,47 cases in each group.Patients of both groups received conventional symptomatic treatment,fasting,maintaining water and electrolyte balance,etc,patients with excessive blood loss are treated with blood transfusion.The control group received endoscopic injection,the observation group was treated with Esomeprazole Sodium Injection on the basis of control group.The efficacy,stop time of bleeding,stop time of hematemesis,stop time of melena,amount of blood loss,occurrence of adverse reactions were compared between two groups,and the levels of hemoglobin,coagulation indexes,hs-CRP,IL-6 and COR before and after intervention were compared between two groups.Result:The total effective rate of observation group was 95.74% higher than 78.72% of control group,and the difference was statistically significant(P<0.05).The stop time of bleeding,stop time of hematemesis,stop time of melena,amount of blood loss of observation group were less than those of control group,the difference were statistically significant(P<0.05).Before intervention,there were no significant differences in the levels of hemoglobin,PT,APTT,PLT,fibrinogen,D-dimer,HCT,hs-CRP,IL-6 and COR between two groups(P>0.05).After intervention,the levels of PT,APTT,fibrinogen,D-dimer,hs-CRP,IL-6 and COR of both groups were lower than before intervention,while the levels of hemoglobin,PLT and HCT were higher than before intervention,the difference were statistically significant(P<0.05).After intervention,the levels of PT,APTT,fibrinogen,D-dimer,hs-CRP,IL-6 and COR of observation group were lower than those of control group,while the levels of hemoglobin,PLT and HCT were higher than those of control group,the difference were statistically significant(P<0.05).The incidence of ADR of observation group was 4.26% lower than 21.28% of control group,and the difference was statistically significant(P<0.05).Conclusion:For patients with acute peptic ulcer hemorrhage,Esomeprazole Sodium Injection combined with endoscopic injection can improve the clinical symptoms of the patients,fast hemostasis,less blood loss,improve the hemoglobin levels and blood coagulation index,improve the hs-CRP,IL-6,COR level,reduce the incidence of adverse reactions,higher application value.