尾加压素Ⅱ与肾脏疾病相关性的研究进展

Research Progress of the Correlation between Urotensinii and Kidney Disease

尾加压素Ⅱ(UrotensinⅡ,UII)是一种具有广泛生物学效应的血管活性肽,在人体中具有很强的血管收缩作用,主要参与心血管疾病以及系统的稳态调节。近年来研究发现UII与肾脏疾病发病机制关系密切,目前发现UII与高血压肾损害、糖尿病肾病、肾肿瘤、IgA肾病、肾病综合征以及慢性肾脏病等肾脏疾病具有相关性。本文就UII与肾脏疾病的相关性进行简述。

Urotensin II(Urotensin II,UII)is a vasoactive peptide with a wide range of biological effects.It has a strong vasoconstrictor effect in the human body and is mainly involved in cardiovascular disease and system homeostasis regulation.In recent years,studies have found that UII is closely related to the pathogenesis of kidney disease.At present,UII has been found to be related to hypertensive kidney damage,diabetic nephropathy,kidney tumors,IgA nephropathy,nephrotic syndrome,and chronic kidney disease.This article briefly describes the relationship between UII and kidney disease.