生殖器丘疹样棘层松解性皮病一例

Papular acantholytic dyskeratosis of genitalia:a case report

报道1例生殖器丘疹样棘层松解性皮病。患者,男,30岁。2年前肛周出现灰白色丘疹,部分融合,伴瘙痒。实验室检查:HPV6阳性,醋酸白试验、梅毒螺旋体明胶凝集试验(TPPA)、HIV均阴性。皮损组织病理示:基底层上方棘层下方多处裂隙,可见棘层松解细胞,中等量淋巴细胞浸润。直接免疫荧光:IgG、IgM、IgA、C3阴性。予以0.03%他克莫司外用6个月后丘疹明显变平,瘙痒缓解。

A case of papuloid acantholysis of genitalia is reported.A 30-year-old male presented with gray white papules around the anus with partial fusion and pruritus for two years.Laboratory examination showed positive for HPV6 and negative for acetic acid white test,Treponema pallidum gelatin agglutination test(TPPA)and HIV.Histopathological examination showed cleft between the basal layer and the spinous layer with acantholytic dyskeratotic cells and lymphocyte infiltration.Direct immunofluorescence:IgG,IgM,IgA and C3 were negative.After 6 months of topical application of 0.03%tacrolimus,the papules subside and the itching was relieved.