肠道微生物群在强迫症发病机制及治疗中的作用研究进展

Research progress of the role of gut microbiota in the pathogenesis and treatment of obsessivecompulsive disorder

强迫症是核心表现为反复出现的闯入性想法或重复行为的一种慢性致残性精神障碍,其病因复杂,发病机制尚未被完全阐明。近年来,微生物群-肠-脑(microbiota-gut-brain,MGB)轴成为精神障碍的研究热点。肠道微生物群作为脑-肠双向联系的关键媒介,在免疫炎症、神经内分泌和大脑发育过程中起着重要作用。该文对MGB轴与强迫症可能的关联及由该轴介导的潜在病因学途径进行综述,并针对肠道微生物群这一新靶点的治疗方案进行探讨。

Obsessive-compulsive disorder(OCD)is a chronic and disabling psychiatric disorder characterized by recurrent intrusive thoughts or repetitive behaviors.However,the etiology is complex and the underlying pathophysiology remains unclear.In recent years,microbiota-gut-brain(MGB)axis has become a research hotspot in the field of psychiatry.Gut microbiota,as a key medium of the bilateral connection between brain and intestine,plays an important role in immune inflammation,neuroendocrine and brain development.This review illustrates possible link between OCD and MGB axis and the underlying etiological pathway.And treatment options targeting the gut microbiome is also further discussed.