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宫颈癌放化疗骨盆骨髓保护与急性血液不良反应关系分析 被引量:1

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摘要 目的分析宫颈癌患者进行同步放化疗时骨盆骨髓保护与急性血液不良反应的关系。方法选取2018年4月-2020年3月襄阳市襄州区人民医院收治的宫颈癌术后患者50例为研究对象,根据随机数字表法分为观察组和对照组,每组25例。2组均进行同步放化疗治疗,观察组治疗时则进行骨盆骨髓保护。比较2组患者平均骨髓照射剂量、骨髓抑制发生情况,并分析两者之间的关系。结果观察组平均骨髓照射剂量为(32.81±3.46)Gy,低于对照组的(40.65±3.97)Gy(t=7.444,P=0.000);观察组骨髓抑制总发生率为32.00%,低于对照组的60.00%(x^(2)=3.945,P=0.048)。在对急性血液不良反应危险因素回归性分析中发现,年龄、肿瘤部位、病理类型、同步放化疗照射面积均是宫颈癌患者同步放化疗时发生急性血液不良反应的独立危险因素。结论宫颈癌患者接受同步放化疗时实施骨盆骨髓保护与急性血液不良反应的发生率呈正相关,减低骨髓照射的剂量可降低急性血液不良反应发生率,有利于治疗的顺利进行。
作者 谢洋 李丽
出处 《临床合理用药杂志》 2021年第23期173-174,共2页 Chinese Journal of Clinical Rational Drug Use
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