中性粒细胞胞外诱捕网在炎症性疾病中的研究进展

Advances in research on the neutrophil extracellular traps in inflammatory diseases

中性粒细胞胞外诱捕网(NETs)的形成过程称为NETosis,是不同于凋亡和坏死的一种新型中性粒细胞死亡方式,其机制包括经典途径及Gasdermin D介导的途径。NETs在炎症性疾病(ID)的发生发展中发挥重要作用。文章就NETs在肿瘤、自身免疫性疾病、心脑血管疾病、糖尿病及感染性疾病等ID中作用的研究进展进行综述。

The state of neutrophil with Neutrophil Extracellular Traps(NETs)formation is termed NETosis,a new type of cell death,which is different from apoptosis and necrosis.Mechanisms of NETosis include classical pathway and Gasdermin D mediated pathway.Some studies have proved that NETs might play important roles in inflammatory diseases(ID).Herein,we review recent advances in the knowledge of NETs in tumor,autoimmune disease,cardiovascular and cerebrovascular disease,diabetes and infectious diseases,and provide fresh ideas for the treatment of ID.