摘要
非痴呆型血管性认知障碍(VCIND)是脑血管损伤所致的早期或轻度认知功能障碍,具有隐匿性和可逆性。外泌体能够介导神经血管单元内细胞间通讯和物质传递,特别是在基因表达中重要的调节作用的外泌体miRNA被广泛研究,在VCIND中扮演着重要角色。文章对外泌体在VCIND的发生发展过程的作用机制、诊断及治疗中的研究进展进行综述。
Vascular cognitive impairment no dementia(VCIND)is an early or mild cognitive impairment caused by cerebrovascular injury,which is latent and reversible.Exosomes can mediate intercellular communication and substance transfer within neurovascular units,especially exosomal miRNAs,which play an important regulatory role in gene expression,have been widely studied and play an important role in VCIND.This article reviews the mechanism,diagnosis and treatment of exosomes in the occurrence and development of VCIND.
作者
梁紫君
郑娜
张雪儿(综述)
安红伟(审校)
LIANG Zi-jun;ZHENG Na;ZHANG Xue-er(reviewing);AN Hong-wei(checking)(Graduate School,Guangxi University of Chinese Medicine,Nanning 530200,Guangxi,China;Department of Neurology,Liuzhou Traditional Chinese Medical Hospital,Liuzhou 545001,Guangxi,China)
出处
《东南国防医药》
2021年第4期401-406,共6页
Military Medical Journal of Southeast China
基金
柳州市科技攻关与新产品试剂项目(2019BJ10611)。
