肠道益生菌联合加兰他敏片对阿尔茨海默病患者认知功能及治疗安全性的影响研究

Effect of intestinal probiotics combined with galantamine tablets on cognitive function and treatment safety in patients with Alzheimer′s disease

目的探讨肠道益生菌联合加兰他敏片对阿尔茨海默病(AD)患者认知功能及治疗安全性的影响。方法选择2018年1月至2019年12月AD患者60例为对象,随机数字表法分为2组。对照组30例采用加兰他敏片联合安慰剂治疗,观察组30例使用加兰他敏片联合肠道益生菌治疗。16周治疗后对患者效果进行评估,比较2组AD评定量表认知部分(ADAS-cog)、血液生化指标、临床副反应量表(TESS)情况。结果2组治疗后4周、8周、12周及16周ADAS-cog评分均低于治疗前(P<0.05);观察组治疗后4周、8周、12周及16周ADAS-cog评分均低于对照组(P<0.05)。2组治疗后16周中性粒细胞/淋巴细胞(NLR)、C反应蛋白(CRP)及降钙素原(PCT)水平低于治疗前(P<0.05);观察组治疗后16周血清NLR、CRP及PCT水平均低于对照组(P<0.05)。2组用药期间头痛、恶心呕吐、头晕嗜睡、肝肾异常及血压升高发生率差异无统计意义(P>0.05)。结论肠道益生菌联合加兰他敏片用于AD患者可提高认知能力,降低患者血常规水平,未增加药物不良反应发生率,值得推广应用。

Objective To investigate the effect of intestinal probiotics combined with galantamine tablets on cognitive function and treatment safety in patients with Alzheimer′s disease(AD).Methods A total of 60 AD patients treated in our hospital between January 2018 and December 2019 were included as subjects,and were divided into two groups by random number table:30 patients in the control group to be treated with galantamine tablets plus placebo,and 30 others in the study group to be treated with galantamine tablets plus intestinal probiotics.After 16 weeks of treatment,the patient outcome was evaluated.The two groups were compared for AD Assessment Scale-Cognitive Subscale(ADAS-cog),blood biochemistry,and score of Treatment Emergent Symptom Scale(TESS).Results At 4,8,12 and 16 weeks after treatment,the ADAS-cog scores in either groups were lower than those at baseline(P<0.05),and was lower in the study group than those in the control group(P<0.05).At 16 weeks after treatment,the levels of serum NLR,CRP and PCT in either group were lower than those at baseline(P<0.05),and were lower in the study group than those in the control group(P<0.05).There were not statistically significant differences in incidence of headache,nausea/vomiting,dizziness,drowsiness,liver and kidney abnormalities,and high blood pressure during medication between the two groups(P>0.05).Conclusion In patients with AD,treatment on intestinal probiotics combined with galantamine tablets can improve cognition and profiles of blood routine tests without increase of adverse drug reactions,and therefore warrants widespread use in clinical practice.