奥曲肽联合注射用艾司奥美拉唑钠治疗胃、十二指肠溃疡出血的临床分析

Clinical Analysis of Octreotide Combined with Esomeprazole Sodium for Injection in the Treatment of Gastric and Duodenal Ulcer Bleeding

目的:观察奥曲肽联合注射用艾司奥美拉唑钠治疗胃、十二指肠溃疡出血的临床应用价值。方法:选取2017年6月-2020年5月本院收治胃、十二指肠溃疡出血患者总计108例。根据随机数字表法分为对照组和观察组,每组54例。对照组进行注射用艾司奥美拉唑钠治疗,试验组进行奥曲肽联合注射用艾司奥美拉唑钠治疗。比较两组临床治疗指标(出血量、输血量、住院时间)、治疗效果、随访6个月再发出血率、治疗前后胃相关指标(胃液pH水平、胃泌素)水平。结果:试验组出血量、输血量明显少于对照组,住院时间短于对照组,差异有统计学意义(P<0.05)。治疗后试验组治疗总有效率(96.30%)高于对照组(75.93%),试验组再发出血率(0)低于对照组(7.41%),差异有统计学意义(P<0.05)。治疗前胃液pH值、胃泌素水平比较差异无统计学意义(P>0.05)。治疗后胃液pH值较治疗前升高,试验组高于对照组, 治疗后胃泌素水平较治疗前降低,试验组低于对照组,差异有统计学意义(P<0.05)。结论:在胃、十二指肠溃疡出血的治疗中,奥曲肽联合注射用艾司奥美拉唑钠可明显减少患者出血量,改善胃液pH水平与胃泌素水平,提升临床疗效,缩短住院时间,并减少再发出血,效果理想。

Objective:To observe the clinical value of Octreotide combined with Esomeprazole Sodium for Injection in the treatment of gastric and duodenal ulcer bleeding.Method:A total of 108 patients with gastric and duodenal ulcer bleeding treated in our hospital from June 2017 to May 2020 were selected.They were divided into the control group and the experimental group according to the random number table method,54 patients in each group.The control group was treated with Esomeprazole Sodium for Injection,and the experimental group was treated with Octreotide combined with Esomeprazole Sodium for Injection.The clinical treatment indexes(bleeding volume,blood transfusion volume,length of stay),therapeutic effect and recurrent bleeding after 6 months of follow-up,gastric related indexes(gastric juice pH,gastrin)before and after treatment were compared between the two groups.Result:The amount of bleeding and blood transfusion in the experimental group were significantly less than those in the control group,and the length of stay in the experimental group was shorter than that in the control group,with significant differences(P<0.05).After treatment,the total effective rate of the experimental group(96.30%)was higher than 75.93%of the control group,and the rebleeding rate of the experimental group(0),which was lower than 7.41%of the control group,with significant differences(P<0.05).There was no significant difference in gastric juice pH value and gastrin before treatment(P>0.05);after treatment,the gastric juice pH value increased than that before treatment,whcih of the experimental group was higher than the control group;after treatment,the gastrin level decreased than that before treatment,whcih of the experimental group was lower than the control group,the differences were significant(P<0.05).Conclusion:In the treatment of gastric and duodenal ulcer bleeding,Octreotide combined with Esomeprazole Sodium for Injection can significantly reduce the bleeding volume of patients,and then reduce the amount of bleeding,improve the gastric pH level and gastrin level,improve the clinical efficacy,shorten the hospitalization time,and reduce the incidence of rebleeding,the effect is ideal.