摘要
目的:探讨半夏泻心汤联合西药治疗原发性胆汁反流性胃炎的有效性及安全性。方法:选择本院2017年6月-2019年6月原发性胆汁反流性胃炎患者122例。随机分为观察组(n=61)与对照组(n=61)。对照组给予奥美拉唑肠溶胶囊和多潘立酮分散片治疗,观察组在对照组基础上结合半夏泻心汤治疗。两组疗程8周。比较两组疗效、治疗前后主要症状积分、炎症因子和胃肠激素,以及不良反应。结果:观察组治疗总有效率(91.80%)高于对照组(73.77%),差异有统计学意义(P<0.05)。两组治疗后腹痛和腹胀积分较治疗前降低(观察组:t=45.488、38.339,对照组:t=21.624、23.439,P<0.05),观察组治疗后腹痛和腹胀积分低于对照组(t=21.187、23.040,P<0.05)。两组治疗后血清TNF-α、IL-6和IL-8水平较治疗前降低(观察组:t=22.632、23.858、23.171,对照组:t=8.043、13.311、11.399,P<0.05),观察组治疗后血清TNF-α、IL-6和IL-8水平低于对照组(t=13.065、12.466、12.599,P<0.05)。治疗后两组血浆GAS水平较治疗前降低,MTL水平较治疗前升高(观察组:t=18.874、23.416,对照组:t=6.537、10.662,P<0.05),观察组治疗后血浆GAS水平低于对照组,MTL水平高于对照组(t=12.523、18.060,P<0.05)。观察组不良反应发生率(4.92%)低于对照组(18.03%),差异有统计学意义(P<0.05)。结论:半夏泻心汤联合西药治疗原发性胆汁反流性胃炎效果良好,可改善患者胃肠激素水平,减轻炎症反应,且不良反应少,用药安全性良好。
Objective:To explore the efficacy and safety of Banxia Xiexin Decoction combined with western medicine in the treatment of primary bile reflux gastritis.Method:A total of 122 patients with primary bile reflux gastritis in our hospital from June 2017 to June 2019 were selected and randomly divided into the observation group(n=61)and the control group(n=61).The control group was treated with Omeprazole Enteric-coated Capsules and Domperidone Dispersible Tablets,the observation group was treated with Banxia Xiexin Decoction on the basis of the control group.Both groups treated 8 weeks.The therapeutic effect,main symptom scores,inflammatory factors and gastrointestinal hormones before and after treatment,and adverse reactions were compared between the two groups.Result:The total effective rate of the observation group(91.80%)was higher than that of the control group(73.77%),and the difference was statistically significant(P<0.05).After treatment,the scores of abdominal pain and abdominal distension in the two groups were lower than those before treatment(the observation group:t=45.488,38.339;the control group:t=21.624,23.439;P<0.05);after treatment,the scores of abdominal pain and abdominal distension in the observation group were lower than those in the control group(t=21.187,23.040,P<0.05).After treatment,the serum levels of TNF-α,IL-6 and IL-8 in the two groups were lower than those before treatment(the observation group:t=22.632,23.858,23.171,the control group:t=8.043,13.311,11.399;P<0.05);after treatment,the levels of TNF-α,IL-6 and IL-8 of the observation group were lower than those of the control group(t=13.065,12.466,12.599;P<0.05).After treatment,the plasma GAS level was lower and MTL level was higher in the two groups than those before treatment(the observation group:t=18.874,23.416,the control group:t=6.537,10.662;P<0.05);after treatment,the plasma GAS level in the observation group was lower than that of the control group,the MTL level was higher than that of the control group(t=12.523,18.060;P<0.05).The incidence of adverse reactions in the observation group(4.92%)was lower than 18.03%of the control group,the difference was statistically significant(P<0.05).Conclusion:Banxia Xiexin Decoction combined with western medicine is effective in treating primary bile reflux gastritis.It can improve gastrointestinal hormones and alleviate inflammation,with fewer adverse reactions and good medication safety.
作者
唐明
TANG Ming(Jianli Hospital of Traditional Chinese Medicine,Jianli 433300,China)
出处
《中外医学研究》
2021年第20期17-20,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
半夏泻心汤
西药
原发性胆汁反流性胃炎
有效性
安全性
Banxia Xiexin Decoction
Western medicine
Primary bile reflux gastritis
Effectiveness
Safety