COPD患者FeNO与FEV_(1)、FEV_(1)/FVC及病情严重程度评价指标的相关性

Correlation between FeNO and FEV_(1),FEV_(1)/FVC and Disease Severity Evaluation Indexes in Patients with COPD

目的:分析COPD患者呼出气一氧化氮(FeNO)与第1秒用力呼气容积(FEV_(1))、FEV_(1)/用力肺活量(FVC)(FEV_(1)/FVC)及病情严重程度评价指标的相关性,为完善COPD患者病情综合评估提供参考。方法:选择本院2019年1-12月本院收治的急性期COPD患者40例作为急性期COPD组,选择同期收治的稳定期COPD患者40例作为稳定期COPD组。对两组分别进行FeNO、FEV_(1)及FEV_(1)/FVC测定,并行组间比较。参照指南对两组行COPD病情综合评估(风险、症状、肺功能分级、急性加重分级、呼吸困难分级、CAT评分)并行组间比较。分析COPD患者FeNO水平与FEV_(1)、FEV_(1)/FVC、风险、症状、肺功能分级、急性加重分级、呼吸困难分级、CAT评分的相关性,探讨FeNO在COPD患者病情严重程度综合评估中的临床意义。结果:(1)急性期COPD组FeNO高于稳定期COPD组,FEV_(1)、FEV_(1)/FVC均低于稳定期COPD组(P<0.05),(2)急性期COPD组风险、症状、肺功能分级、急性加重分级、呼吸困难分级、CAT评分均高于稳定期COPD组(P<0.05),(3)COPD患者FeNO水平与FEV_(1)、FEV_(1)/FVC呈负相关,与症状、肺功能分级、呼吸困难分级、CAT评分呈正相关(r>0.5,P<0.05)。结论:FeNO与COPD患者病情严重程度高度相关,且检测方便快捷,其作为COPD患者病情严重程度评估指标可有效避免现有COPD患者病情严重程度评估指标大多具有较强的主观性的问题,具有较高的临床价值。

Objective:To analyze the correlation between fractional exhaled nitric oxide(FeNO)and forced expiratory volume in one second(FEV_(1)),FEV_(1)/forced vital capacity(FVC)(FEV_(1)/FVC)and disease severity evaluation indexes in patients with chronic obstructive pulmonary disease(COPD),so as to provide reference for improving the comprehensive assessment of COPD patients.Method:A total of 40 patients with acute COPD admitted to our hospital from January to December 2019 were selected as the acute COPD group,and 40 patients with stable COPD admitted to our hospital during the same period were selected as the stable COPD group.The levels of FeNO,FEV_(1)and FEV_(1)/FVC were measured in the two groups,and the results were compared between the two groups.According to the guidelines,the two groups were evaluated for COPD(risk,symptoms,pulmonary function grade,acute exacerbation grade,dyspnea grade,CAT score)and compared between the two groups.Analyzed the correlation between FeNO level and FEV_(1),FEV_(1)/FVC,risk,symptoms,pulmonary function grade,acute exacerbation grade,dyspnea grade and CAT score in COPD patients,explored the clinical significance of FeNO in the comprehensive assessment of the severity of COPD patients.Result:(1)The level of FeNO of the acute COPD group was higher than that in the stable COPD group,the levels of FEV_(1)and FEV_(1)/FVC were lower than those in the stable COPD group(P<0.05).(2)The risk,symptoms,pulmonary function grade,acute exacerbation grade,dyspnea grade and CAT score of the acute COPD group were higher than those in the stable COPD group(P<0.05).(3)The FeNO level in COPD patients was negatively correlated with FEV_(1),FEV_(1)/FVC,and positively correlated with symptom,pulmonary function grade,dyspnea grade,CAT scores(r>0.5,P<0.05).Conclusion:FeNO is highly correlated with the severity of COPD,and its detection is convenient and fast.As a severity assessment index of COPD patients,FeNO can effectively avoid most of the existing severity assessment indicators of COPD patients with strong subjective problems,and has high clinical value.