盐酸利托君联合硫酸镁治疗先兆早产患者的效果及对妊娠和新生儿结局的影响

Effect of Ritodrine Hydrochloride Combined with Magnesium Sulfate in Patients with Threatened Preterm Labor and Its Effect on Pregnancy and Neonatal Outcomes

目的:研究盐酸利托君联合硫酸镁治疗先兆早产患者的效果及对妊娠和新生儿结局的影响。方法:选取2018年10月-2019年10月于笔者所在医院就诊的先兆早产的患者72例,按照随机数字表法分为对照组和观察组,均为36例。对照组予以硫酸镁治疗,观察组在对照组的基础上予以盐酸利托君治疗。观察两组患者保胎成功情况、宫缩消除时间、症状消失时间及孕周延长时间、新生儿结局及不良反应发生情况。结果:观察组保胎成功率为94.44%,明显高于对照组的75.00%(P<0.05);观察组宫缩消除时间、症状消失时间早于对照组(P<0.05),孕周延长时间长于对照组(P<0.05);观察组Apgar评分、出生时体质量均高于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:盐酸利托君联合硫酸镁治疗先兆早产患者可以提高保胎效果,更快地缓解症状及抑制宫缩,通过延长孕周提高新生儿质量,不会增加不良反应。

Objective:To investigate the effect of Ritodrine Hydrochloride combined with Magnesium Sulfate in patients with threatened preterm delivery and the effect on their pregnancy and neonatal outcomes.Method:Seventy two patients with threatened preterm labor who visited our hospital from October 2018 to October 2019 were selected and divided into control and observation groups according to the random number table method,which were 36 cases each.The control group was treated with Magnesium Sulfate,and the observation group was treated with Ritodrine Hydrochloride on the basis of the control group.The success of tocolysis,elimination time,disappearance time of symptoms and prolongation of gestational week,neonatal outcome and occurrence of adverse effects were observed in both groups.Result:The success rate of tocolysis in the observation group was 94.44%,which was significantly higher than 75.00%in the control group(P<0.05).The time of elimination of contractions and disappearance of symptoms were earlier than those in the control group(P<0.05).The prolongation of gestational week was longer than that in the control group(P<0.05).The Apgar scores and body mass at birth in the observation group were higher than those in the control group(P<0.05),and the rates of adverse effects in the two groups were not significantly different(P>0.05).Conclusion:Ritodrine Hydrochloride combined with Magnesium Sulfate in patients with threatened preterm labor can improve the fetal protection effect,relieve symptoms and inhibit contractions faster,and improve the quality of newborns by prolonging the gestational week without increasing adverse effects.