微生态制剂协同抗生素治疗ICU重症肺部感染的临床效果

Clinical effect of microecological agents and antibiotics in the treatment of severe pulmonary infection in ICU

目的观察微生态制剂协同抗生素治疗ICU重症肺部感染的临床效果。方法筛选2018年12月-2019年11月湖南中医药大学第二附属医院收治的ICU重症肺部感染患者72例,按照电脑随机数字表法分为研究组和对照组各36例。对照组进行抗生素治疗,研究组进行微生态制剂协同抗生素治疗。比较2组治疗前后的动脉血氧分压(PaO2)、二氧化碳分压(PaCO2)、白细胞计数(WBC)、临床疗效、并发症及临床指标。结果治疗后,2组PaO2高于治疗前,PaCO2及WBC低于治疗前,且研究组升高/降低幅度大于对照组,差异均有统计学意义(P<0.05)。研究组临床治疗总有效率(97.22%)高于对照组(83.33%),差异有统计学意义(x^(2)=3.956,P=0.047)。研究组并发症总发生率(5.56%)低于对照组(25.00%),差异有统计学意义(x^(2)=5.258,P=0.022)。研究组症状消失时间、机械通气时间、体温恢复时间及住院时间均短于对照组,差异均有统计学意义(P<0.01)。结论微生态制剂协同抗生素治疗ICU重症肺部感染可提高临床治疗有效率,改善PaO2、PaCO2、WBC指标,且并发症发生率较低,值得在实际临床中进一步推广。

Objective To observe the clinical effect of microecological agents combined with antibiotics in the treatment of severe pulmonary infection in ICU. Methods A total of 72 patients with severe pulmonary infection in ICU who were admitted to the Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine from December 2018 to November 2019 were selected,according to the computerized random number table,they were divided into study group and control group,36 cases in each group. The control group was treated with antibiotics,and the study group was treated with microecological agents and antibiotics. The oxygen partial pressure( Pa O2),carbon dioxide partial pressure( Pa CO2),white blood cell count( WBC) before and after treatment,clinical efficacy,complications and clinical indicators of the two groups were compared. Results After treatment,Pa O2 in the two groups was higher than before treatment,Pa CO2 and WBC were lower than before treatment,and increase/decrease of the study group were greater than that in the control group,the differences were statistically significant( P < 0. 05). The total effective rate of clinical treatment in the study group( 97. 22%) was higher than that in the control group( 83. 33%),and the difference was statistically significant( χ2= 3. 956,P = 0. 047). The incidence of complications in the study group( 5. 56%) was lower than that in the control group( 25. 00%),and the difference was statistically significant( χ2= 5. 258,P = 0. 022). The symptom disappearance time,mechanical ventilation time,body temperature recovery time and hospitalization time in the study group were shorter than those in the control group,and the differences were statistically significant( P < 0. 01). Conclusion The treatment of severe pulmonary infections in ICU with microecological agents and antibiotics can improve the clinical treatment efficiency,improve Pa O2,Pa CO2,WBC indicators,and have a lower incidence of complications,it is worthy of further promotion in actual clinical practice.