培门冬酶相关胰腺炎患儿门冬酰胺酶再暴露1例

A case of asparaginase reexposure in a child with asparagase-associated pancreatitis

目的探讨临床药师参与门冬酰胺酶相关胰腺炎的急性淋巴细胞白血病患儿治疗方案的制定及药学监护要点。方法临床药师通过查阅文献参与1例门冬酰胺酶相关胰腺炎患儿门冬酰胺酶再暴露的治疗方案制定,对患儿进行用药教育及药学监护,以确保化疗方案顺利完成。结果临床药师协助医师为患儿制定化疗方案,进行用药教育及药学监护,门冬酰胺酶相关胰腺炎患儿门冬酰胺酶再暴露时顺利完成化疗方案。结论门冬酰胺酶相关胰腺炎患儿当病情需要时可考虑再次使用门冬酰胺酶,再暴露时药师应协助医师做好用药教育及药学监护。

Objective To explore the clinical pharmacists involved in the formulation of treatment plan and pharmaceutical care of children with acute lymphoblastic leukemia with asparaginase-associated pancreatitis.Methods Clinical pharmacists participated in the formulation of treatment plan for asparaginase reexposure in a child with asparaginase-related pancreatitis through literature review,and provided medication education and pharmaceutical care to the child to ensure the successful completion of chemotherapy plan.Results Clinical pharmacists assisted physicians in formulating chemotherapy regimens for children with asparaginase-associated pancreatitis,providing medication education and pharmaceutical care,and successfully completed chemotherapy regimens for children with asparaginase-associated pancreatitis when asparaginase-associated pancreatitis was reexposed.Conclusion Asparaginase-related pancreatitis in children should be considered to use asparaginase-related pancreatitis again when the condition requires,and pharmacists should assist physicians to do a good job in medication education and pharmaceutical care when reexposed.