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阿德福韦酯相关性低血磷性骨软化症1例 被引量:1

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摘要 慢性乙型肝炎(CHB)属肝炎疾病,临床往往给予药物治疗,以抑制患者HBV复制,部分严重的患者甚至需终生服药抑制病毒[1]。阿德福韦酯(ADV)常用于CHB抗病毒治疗,常规剂量(10mg/d)可有效抑制病毒,而且安全有效[2]。然而2009年,相关研究中给予患者ADV常规剂量治疗,持续治疗2年后发生低磷骨软化,这引起了医学界的关注,此后越来越多的研究报道此类病例,部分病情严重的患者甚至发生低血磷性骨软化症[3-4]。
作者 廖燕婷
出处 《临床合理用药杂志》 2021年第22期162-163,共2页 Chinese Journal of Clinical Rational Drug Use
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  • 1Masami Minemura,Yoshiharu Tokimitsu,Kazuto Tajiri,Yasuhiro Nakayama,Kengo Kawai,Hiroshi Kudo,Katsuharu Hirano,Yoshinari Atarashi,Yutaka Yata,Satoshi Yasumura,Terumi Takahara,Toshiro Sugiyama.Development of osteomalacia in a post-liver transplant patient receiving adefovir dipivoxil[J].World Journal of Hepatology,2010,2(12):442-446. 被引量:13
  • 2Chinese Society of Hepatology and Chinese Society of Infectious Diseases,Chinese Medical Association. 42 Dongsi Xidajie,Beijing 100710,China.慢性乙型肝炎防治指南[J].中华肝脏病杂志,2005,13(12):881-891. 被引量:1931
  • 3Chen C.-J.,Yang H. -I.,Su J.,王铮(译),陈云茹(校).血清乙型肝炎病毒DNA水平的生物学梯度与肝细胞肝癌的风险性相关[J].世界核心医学期刊文摘(胃肠病学分册),2006,2(6):1-1. 被引量:225
  • 4Viganh M1, Lampertieo P, Colombo M. Drug safety evaluation of ade- fovir in HBV infection[J]. Expert Opin Drug Saf, 2011, 10(5) : 809-818.
  • 5Lee H J, Choi JW, Kim TN, et ah A case of severe hypnphosphatemia related to adefovir dipivoxil treatment in a patient with liver cirrhusis re- lated to hepatitis B virus [J]. KoreanJ Hepatol, 2008, 14(3): 381- 386.
  • 6Izzedine H, Kheder ER, Housset P, et ah Adefovir dipivoxil induced acute tubular necrosis and Faneoni syndrome in a renal transplant pa- tient [J]. AIDS, 2009, 23(4): 544-545.
  • 7Hartono JL, Aung MO, Data YY, et al. Resolution of adefovir-related nephrotoxicity by adefovir dose-reduction in patients with chronic hepa- titis B [J]. Aliment Pharmacol Ther, 2013, 37(7): 710-719.
  • 8Law ST, Li KK, Ho YY. Nephrotoxieity, inch.lding acquired Fanconi' s syndrome, caused by adefovir dipivoxil-is there a safe dose? [J]. J Clin Pharm Ther, 2012, 37(2): 128-131.
  • 9Uwai Y, Ida H, Tsuji Y, et al. Renal transport of adefovir, eidofo- vir, and tenofovir by SLC22A family members (hOATI , hOAT3, and hOCT2) [J]. Pharm Res, 2007. 24(4): 811-815.
  • 10hnaoka T, Kusuhara H, Adachi M, et al. Funetional involvement of muhidrug resistance-associated protein 4 (MRP4/ABCC4) in the re- nal elimination of the antiviral drugs adefovir and tenofovir [ J]. Mol Pharmacol, 2007, 71 (2): 619-627.

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