血清CG及TBA水平预测妊娠期肝内胆汁淤积症患者早产的价值

Value of serum CG and TBA levels in predicting premature delivery of patients with intrahepatic cholestasis in pregnancy

目的分析血清甘胆酸(CG)与总胆汁酸(TBA)水平预测妊娠期肝内胆汁淤积症(ICP)患者早产的价值。方法回顾性分析2016年1月至2020年6月晋城大医院收治的82例ICP患者的临床资料,将其中发生早产的12例患者纳入发生早产组,其余70例患者纳入未发生早产组。比较两组患者的一般资料及实验室指标,分析血清CG、TBA水平预测ICP患者早产的价值。结果发生早产组血清CG、TBA水平分别为(66.65±3.05)μg/ml、(25.12±1.42)μmol/L,均高于未发生早产组的(35.62±4.03)μg/ml及(15.13±1.29)μmol/L,P<0.05。绘制受试者工作特征曲线显示,血清CG、TBA单项及联合检测预测ICP患者早产风险的曲线下面积分别为0.826、0.821、0.913,以联合检测的预测效能最好。结论血清CG、TBA水平与ICP患者早产的发生有关,二者高表达可增加ICP患者早产风险,对预测IPC患者早产有一定的价值。

Objective To analyze the value of serum glycocholic acid(CG)and total bile acid(TBA)levels in predicting premature delivery of patients with intrahepatic cholestasis in pregnancy(ICP).Methods The clinical data of 82 patients with ICP admitted to Jincheng General Hospital from January 2016 to June 2020 were retrospectively analyzed.Among the 82 patients,12 patients with premature delivery were included in the premature delivery group,and the remaininy 70 patients werd included in the non-premature delivery group.The general information and laboratory parameters of the patients in two group were compared,and the value of serum CG and TBA levels in predicting premature delivery in patients with ICP were analyzed.Results The levels of serum CG and TBA in the premature delivery group were(66.65±3.05)μg/ml and(25.12±1.42)μmol/L,higher than the(35.62±4.03)μg/ml and(15.13±1.29)μmol/L in the non-premature delivery group(P<0.05).Receiver operating characteristic curve showed that the area under the curve of single and combined detection of serum CG and TBA in predicting the risk of premature birth in ICP patients were 0.826,0.821 and 0.913,respectively,and the prediction efficiency of combined detection was the best.Conclusions The serum levels of CG and TBA are related to the occurrence of premature delivery in ICP patients.The high expression of CG and TBA can increase the risk of premature delivery in ICP patients,which has a certain value in predicting premature delivery in ICP patients.