血栓通联合补阳还五汤加减治疗脑梗死后遗症的效果观察

Therapeutic effect of Xueshuantong modified combined with Buyang Huanwu decoction on sequelae of cerebral infarction

目的分析补阳还五汤加减联合血栓通治疗脑梗死后遗症的效果。方法抽取2019年1月至2020年1月许昌市第二人民医院收治的脑梗死后遗症患者70例,按随机数字表法分为对照组和观察组,每组35例。对照组给予血栓通治疗,观察组在此基础上增加补阳还五汤加减。比较两组生活自理能力量表(ADL)评分、简明健康状况量表(SF-36)评分,治疗前后美国国立卫生院卒中量表(NIHSS)评分、血浆比及全血比黏度及红细胞聚集指数,总有效率及不良反应发生率。结果观察组ADL评分、SF-36评分分别为(88.21±4.25)、(92.75±4.21)分,高于对照组的(79.56±2.31)、(79.21±2.12)分,P<0.05。治疗前,两组NIHSS、血浆比以及全血比黏度、红细胞聚集指数比较差异未见统计学意义(P>0.05);治疗后,两组NIHSS、血浆比以及全血比黏度、红细胞聚集指数均改善,且观察组NIHSS、血浆比以及全血比黏度、红细胞聚集指数低于对照组(P<0.05)。观察组总有效率(94.29%,33/35)高于对照组(74.29%,26/35),P<0.05。两组不良反应发生率比较差异未见统计学意义(P>0.05)。结论血栓通联合补阳还五汤加减治疗脑梗死后遗症的效果确切,可有效改善患者的血液流变学指标及神经功能,提高其生活自理能力和生存质量,安全性高。

Objective To analyze the therapeutic effect of modified Buyang Huanwu decoction combined with Xueshuantong on sequelae of cerebral infarction.Methods Seventy patients with sequelae of cerebral infarction treated in Xuchang Second People’s Hospital from January 2019 to January 2020 were selected and divided into control group and observation group by random number table method,with 35 cases in each group.Patients in control group were treated with Xueshuantong,and patients in observation group were treated by modified Buyang Huanwu decoction based on treatment of control group.The scores of the activity of daily living(ADL),the medical outcomes study 36-item short-form health survey(SF-36),the National Institutes of Health Stroke Scale(NIHSS),plasma ratio,whole blood viscosity,erythrocyte aggregation index before and after treatment,total effective rate and adverse reactions were compared between the two groups.Results The scores of ADL and SF-36 in observation group(88.21±4.25,92.75±4.21)were higher than those in control group(79.56±2.31,79.21±2.12),P<0.05.Before treatment,there was no significant difference in NIHSS,plasma ratio,whole blood viscosity and erythrocyte aggregation index between the two groups(P>0.05).After treatment,NIHSS,plasma ratio,whole blood viscosity and erythrocyte aggregation index were improved in both groups,and those indexes in observation group were significantly lower than those in control group(P<0.05).The total effective rate of observation group(94.29%,33/35)was higher than that of control group(74.29%,26/35),P<0.05.There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Xueshuantong combined with modified Buyang Huanwu decoction is effective in treating sequelae of cerebral infarction,which can effectively improve the hemorheological index and nerve function of patients,improve the self-care ability and quality of life of patients,and has high safety.