KDM4A的结构、功能及其在肿瘤中作用的研究进展

Advances in the structure and functions of KDM4A and its roles in cancer

组蛋白甲基化是一种重要的表观遗传修饰,而赖氨酸特异性去甲基化酶4A(KDM4A,也称JMJD2A)能特异性催化组蛋白赖氨酸残基的去甲基化过程,从而调节染色质的结构和基因转录。近年来研究发现,KDM4A参与调控了细胞增殖、分化、发育、代谢等多种重要的生物学进程,其功能异常也和肿瘤等疾病的发生发展密切相关,成为未来肿瘤治疗的重要靶点。KDM4A在肿瘤中的作用是目前的研究热点,该文就KDM4A的结构、作用机制、生物学功能、在肿瘤中作用及抑制剂开发的最新研究进展作一综述。

Histone methylation is an important epigenetic modification,and lysine(K)-specific demethylase 4A(KDM4A,also known as JMJD2A)specifically catalyzes the demethylation of lysine residues of histone proteins,thereby regulating chromatin structure and gene transcription.Recent studies have showed that KDM4A is involved in the regulation of multiple processes including cell proliferation,differentiation,development,and metabolism.Dysregulation of KDM4A is closely related to the onset and development of malignant tumors,making KDM4A a promising target for anti-cancer therapy.Therefore,KDM4A has been becoming a hot topic in cancer research.In this review,we discuss the structure,regulation,catalytic activity,and biological functions of KDM4A,as well as its roles in cancer treatment.