PDCD5在自身免疫性疾病中的调控作用及其机制

Regulatory effect and the molecular mechanism of PDCD5 in autoimmune diseases

程序性细胞死亡分子5 (programmed cell death 5, PDCD5)是PDCD家族的重要成员之一,具有多种生物学活性,如程序性细胞死亡、细胞周期、胚胎发育以及免疫调节等。PDCD5的表达受多种因素调控,能够通过PDCD5-TIP60-FOXP3途径促进调节性T细胞功能。临床研究证实PDCD5在多种自身免疫病患者的外周血、组织液及组织器官中表达异常,且与疾病的发生发展密切相关。该综述聚焦PDCD5对自身免疫性疾病的影响以及分子调控机制。

Programmed cell death 5(PDCD5) is one of the important members of the PDCD family. It has been shown to be involved in a variety of biological activities, including programmed cell death, cell cycle, embryonic development and immunomodulation. PDCD5 expression is regulated by many factors. It promotes regulatory T cell function via the PDCD5-TIP60-FOXP3 pathway. Clinical studies have confirmed that PDCD5 is abnormally expressed in the peripheral blood, tissue fluid and organs of patients with a variety of autoimmune diseases. This review focuses on the effects of PDCD5 on autoimmune diseases and the underlying molecular mechanism.