表观遗传修饰在学习记忆中的研究进展

Research Progress of Epigenetic Modification in Learning and Memory

学习记忆是大脑的重要功能.记忆的形成涉及基因转录、新蛋白质合成和突触可塑性改变等一系列分子和细胞乃至神经环路的变化.近些年研究者逐渐发现各种表观遗传修饰,包括DNA甲基化、组蛋白修饰及RNA修饰在各种学习记忆类型、记忆阶段和突触可塑性中发挥了不同程度的作用.本文阐述了参与学习记忆的不同表观遗传调控因子,为进一步理解学习记忆的机制提供一定的理论依据.

Learning and memory are important works of brain. Formation of memory involves a series of molecular and cellular changes which including gene transcription, de novo protein synthesis and synaptic plasticity alterations. The studies discussed here strongly indicate that various epigenetic modifications, including DNA methylation, histone modification and RNA modification, play an integral role in learning and memory, and has garnered the attention of researchers in the past decade. In this Review, we examine the involvement of different epigenetic regulators involved in memory and learning functions and provide a theoretical basis for future research.