环状RNA调控TBK1表达影响肿瘤发生发展

The Regulation of Circular RNA to TBK1 in The Pathogenesis of Tumors

TANK结合酶1(TANK-binding kinase 1,TBK1)是一种丝氨酸/苏氨酸激酶,在机体先天免疫调节、细胞选择性自噬、细胞凋亡、细胞再生中发挥重要作用,与肿瘤的发生密切相关.环状RNA(circle RNA,circRNA)是新型的闭合环状非编码RNA,其生物功能及与肿瘤的联系受到国内外学者广泛关注.近年来,越来越多的研究发现,TBK1能与circRNA相互作用,对肿瘤的发生发展产生影响,这暗示了circRNA联合TBK1在肿瘤靶向治疗中的巨大潜力,为肿瘤精准治疗提供了新思路.本文总结了近10年来TBK1与circRNA在肿瘤中的研究,分析两者相互作用的模式,以期为肿瘤的靶向治疗提供新靶点.

The TANK-binding kinase 1(TBK1) is a serine and threonine kinase. It plays important roles in regulating biological functions of the body, such as sequestering the innate immunity, modulating the cell selective autophagy, regulating the apoptosis, and monitoring the cell regeneration. These mechanisms emphasize that TBK1 is inseparable from tumors, which also means inhibiting the biological function of TBK1 may induce an antitumor immune response. The circle RNA(circRNA) is a novel class of the no-coding RNA with the fixed loop structure and proved to influence on many kinds of tumor, such as gastric cancer, lung cancer, colon cancer and liver cancer, attracting the widespread concern from the scholars. Recent evidence suggests TBK1 interacts with circRNA directly, affecting the developments and the differentiation of the tumor cell. These analyses have showed the interaction between TBK1 and circRNA, which can promote the formation of cytokines and chemokines in the tumor microenvironment, reflecting the great potential of them in the tumor targeted therapy. In order to analyze their interation patterns and shed new light on the tumor targeted therapy, this paper summarizes the research on TBK1 and circRNA in tumors in the past 10 years.