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血清miRNA-223与miRNA-210在急性脑梗死中的作用机制及其与炎症因子表达的相关性 被引量:4

Expression and clinical significance of serum miRNA-223 and miRNA-210 in patients with acute cerebral infarction
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摘要 目的探讨急性脑梗死患者血清miRNA-223与miRNA-210的表达及临床意义。方法选择2017年10月—2019年10月60例急性脑梗死患者,并选择60例健康体检者为对照组。检测2组血清miRNA-223、miRNA-210及CRP、IL-6表达水平,分析miRNA-223、miRNA-210水平与CRP、IL-6表达及GOS评分和NIHSS评分的相关性。结果脑梗死组血清miRNA-223、miRNA-210表达明显上调,与对照组比较,差异有统计学意义(P<0.05)。脑梗死组血清CRP、IL-6表达明显较对照组增高,差异有统计学意义(P<0.05)。脑梗死组患者血清miRNA-223、miRNA-210的表达水平与GOS评分均呈正相关(r值分别为0.594、0.657,P<0.001),而与NHISS评分呈均负相关(r值分别为-0.368、-0.429,P<0.01)。脑梗死组患者miRNA-223、miRNA-210表达与血清炎症细胞因子CPR、IL-6表达水平均无相关性(P>0.05),脑梗死组患者血清炎症细胞因子CPR、IL-6表达水平与GOS评分、NHISS评分均无相关性(P>0.05)。结论血清miRNA-223和miRNA-210可能成为急性脑梗死的早期诊断的生物标志物,与患者神经系统损伤程度和预后密切相关。 Objective To investigate the expression and clinical significance of serum miRNA-223 and miRNA-210 in patients with acute cerebral infarction.Methods From October 2017 to October 2019,60 patients with acute cerebral infarction and 60 healthy subjects were selected as control group.The levels of miRNA-223,miRNA-210,CRP and IL-6 in the two groups were detected,and the correlation between the levels of miRNA-223,miRNA-210 and the expression of CRP,IL-6,GOS score and NIH SS score was analyzed.Results The expression of serum miRNA-223,miRNA-210 in the cerebral infarction group was significantly higher than that in the control group,with the difference statistically significant(P<0.05).The expression of serum CRP and IL-6 in the cerebral infarction group was significantly higher than that in the control group,with the difference statistically significant(P<0.05).The expression of serum miRNA-223,miRNA-210 in cerebral infarction group was positively correlated with GOS score(r=0.594,r=0.657,P<0.001),but negatively correlated with NHISS score(r=-0.368,r=-0.429,P<0.01).There was no correlation between the expression of miRNA-223,miRNA-210 and the expression of serum inflammatory cytokines CPR and IL-6 in patients with cerebral infarction(P>0.05).There was no correlation between the expression of serum inflammatory cytokines CPR and IL-6 and GOS score and NHISS score in cerebral infarction group(P>0.05).Conclusion Serum miRNA-223 and miRNA-210 may be biomarkers for early diagnosis of acute cerebral infarction and are closely related to the degree of nervous system injury and prognosis.
作者 金晶 JIN Jing(Department of Neurology,Zhuji People's Hospital,Zhuji,Zhejiang 311800,China)
出处 《中国卫生检验杂志》 CAS 2021年第13期1593-1596,共4页 Chinese Journal of Health Laboratory Technology
基金 浙江省中西医结合学会科研基金项目(2016LYK023)。
关键词 急性脑梗死 miRNA-223 miRNA-210 炎症因子 NIHSS评分 GOS评分 Acute cerebral infarction miRNA-223 miRNA-210 Inflammatory factor NIH SS score GOS score
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