改进后的高荧光淋巴细胞百分比、未成熟粒细胞百分比在经皮肾镜取石术后尿源性脓毒血症中的诊断价值

The diagnostic value of improved hyperfluorescent lymphocytes ratio and immature granulocyte ratio in urosepsis after percutaneous nephrolithotomy

目的探讨改进后的高荧光淋巴细胞(HFLC)百分比和未成熟粒细胞(IG)百分比在诊断经皮肾镜取石术(PCNL)后并发尿源性脓毒血症的临床价值。方法将2018年1月—2019年12月收治的上尿路结石行PCNL患者502例分成术后尿路无感染组、尿路一般感染组和尿脓毒症组3组,分别检测3组HFLC百分比、IG百分比、白细胞计数(WBC)、C-反应蛋白(CRP)、降钙素原(PCT),进行统计学分析。结果尿脓毒症组HFLC百分比、IG百分比、CRP、PCT水平与其他2组比较差异均有统计学意义(P<0.05)。Logistic回归分析显示,HFLC百分比、IG百分比、PCT水平升高是并发尿脓毒症的高危因素(P<0.05),其中HFLC百分比OR值最高,为18.176。三者联合检测ROC曲线下面积为0.960。结论指标HFLC百分比、IG百分比对PCNL并发尿源性脓毒血症的早期诊断有较高的临床价值,值得推广。

Objective To investigate the clinical value of the improved hyperfluorescent lymphocytes ratio(HFLC%)and immature granulocyte ratio(IG%)in the diagnosis of urosepsis after percutaneous nephrolithotomy(PCNL).Methods From January 2018 to December 2019,502 patients with upper urinary tract stones treated with PCNL were divided into three groups:the group without postoperative urinary tract infection,the group with general urinary tract infection and the group with urosepsis.HFLC%,IG%,WBC,CRP and PCT were detected in the three groups for statistical analysis.Results The levels of HFLC%,IG%,CRP and PCT in urosepsis group were significantly different from the other two groups.Logistic regression analysis showed that HFLC%,IG%and PCT were the high risk factors of urosepsis.The highest value of HFLC%OR was 18.176.The area of ROC combined detection of the three was 0.960.Conclusion The improved index of HFLC%and IG%have high clinical value in the early diagnosis of urosepsis after percutaneous nephrolithotomy and are worth popularizing.