微波理疗联合头孢西丁、甲硝唑治疗盆腔炎的疗效及其对局部免疫功能的影响

Effect of microwave physiotherapy combined with cefoxitin and metronidazole in the treatment of pelvic inflammation disease and its effect on local immune function

目的分析微波理疗联合头孢西丁、甲硝唑治疗盆腔炎的疗效及其对局部免疫功能的影响。方法选取2017年1月至2019年12月四川省乐山市中医医院收治的300例盆腔炎患者作为研究对象。以单盲随机抽样法分为实验组和参照组,每组150例。参照组采纳头孢西丁、甲硝唑治疗,实验组在参照组基础上采纳微波理疗治疗,比较两组的临床疗效、血清炎症因子指标、免疫功能指标、不良反应发生率。结果实验组临床总有效率(98.00%)高于参照组(88.00%),实验组治疗后血清肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)、超敏C反应蛋白(hs-CRP)水平均低于参照组,实验组治疗后CD4^(+)、CD4^(+)/CD8^(+)均高于参照组,实验组治疗后CD8^(+)低于参照组,差异具有统计学意义(P<0.05)。实验组不良反应发生率(3.33%)与参照组(2.67%)比较,差异无统计学意义(P>0.05)。结论微波理疗联合头孢西丁、甲硝唑可有效缓解盆腔炎患者临床症状,减轻炎症反应,改善免疫功能,且不良反应较少,值得借鉴。

Objective To analyze the effect of microwave physiotherapy combined with cefoxitin and metronidazole in the treatment of pelvic inflammatory disease and its effect on local immune function. Methods 300 patients with pelvic inflammatory disease treated in Leshan Hospital of Traditional Chinese Medicine from January 2017 to December 2019 were selected as the research subjects. By single blind random sampling, they were divided into the reference group and the experimental group, with 150 cases in each group. The reference group was treated with cefoxitin and metronidazole, and the experimental group was treated with microwave physiotherapy on the basis of the reference group. The clinical efficacy, serum inflammatory factors, immune function indexes and the incidence of adverse reactions were compared between the two groups. Results The total clinical response rate of the experimental group(98.00%) was higher than that of the reference group(88.00%). The serum levels of tumor necrosis factor-α(TNF-α), interleukin-2(IL-2) and hypersensitive C-reactive protein(hs-CRP) in the experimental group were lower than those in the reference group after treatment. The levels of CD4^(+) and CD4^(+)/CD8^(+) in the experimental group were higher than those in the reference group after treatment. CD8^(+) in the experimental group was lower than that in the reference group after treatment(P<0.05). There was no significant difference in the incidence of adverse reactions between the experimental group(3.33%) and the reference group(2.67%)(P>0.05). Conclusions Microwave physiotherapy combined with cefoxitin and metronidazole can effectively alleviate the clinical symptoms of patients with pelvic inflammatory disease, reduce inflammatory reaction, improve immune function, and less adverse reactions, which is worthy of reference.