GUN1调控质体/叶绿体蛋白稳态的分子机制

Mechanisms for the regulation of chloroplast/plastid proteostasis by GUN1

细胞内蛋白稳态(proteostasis)的维持对机体正常生长发育至关重要。在植物细胞中,质体/叶绿体作为半自主细胞器,具有由核基因组和自身基因组编码的蛋白构成的蛋白质组。因此,质体中蛋白稳态的维持不仅需要质体自身调控,还需要其与细胞核之间通过逆行信号进行协调。GUN1 (GENOMES UNCOUPLED 1)被认为是介导质体逆行信号的中央枢纽。最新研究结果进一步揭示GUN1在多维度参与调控质体蛋白稳态。本文重点综述GUN1调控质体蛋白稳态分子机制的研究进展。

The maintenance of protein homeostasis(proteostasis) is essential for organism’s normal growth and development. In plant cells, the chloroplast/plastid, as a semi-autonomous organelle, possesses a proteome that consists of proteins encoded by both the nuclear and its own genomes. Thus, the maintenance of plastid proteostasis is not only depended on the plastid’s self-regulation mechanism, but also needs its fine coordination with the nucleus through the retrograde communication. GUN1(GENOME UNCOUPLED 1) is known as a central hub mediating the chloroplast-to-nucleus retrograde signaling. However, several recent studies have stated that GUN1 is also required for the self-regulation of plastid proteostasis through multiple pathways. Here, we summarizes advances in the molecular mechanism by which GUN1 maintains the plastid proteostasis.