特应性皮炎皮肤屏障受损与“风性开泄”义理钩玄

Discussion on atopic dermatitis skin barrier damage and‘windy venting’

风性开泄指风邪“开玄府,泄津液,携邪入”。特应性皮炎(AD)是一种常见的慢性炎症性皮肤病,表现为湿疹样皮疹和剧烈瘙痒。其发病机制可能因皮肤屏障功能相关的多种终末分化蛋白表达下降,经表皮水分丢失增加;同时,外界环境中的变应原进入表皮,诱发炎症反应,此病理过程与“风性开泄”致病特点异曲同工。故文章主要阐述“风性开泄”之理与AD表皮屏障功能受损二者之间的联系以及表明祛风药对修复其表皮屏障功能的意义。

Windy venting refers to the wind-evil‘open xuanfu,venting fluid,carrying evil spirits’.Atopic dermatitis(AD)is a common chronic inflammatory skin disease characterized by eczema-like rash and severe itching.Its pathogenesis may be due to decreased expression of various terminal differentiation proteins related to skin barrier function,and increased trans epidermal water loss(TEWL).At the same time,allergens in the external environment enter the epidermis,induce inflammation,etc.,and similar to the characteristics of windy venting.Therefore,the article mainly describes the relationship between the principle of‘windy venting’and the destruction of AD epidermal barrier function and the significance of wind-dispelling drugs to repair its epidermal barrier function.