摘要
以往关于颗粒酶B的研究热点是其进入细胞内诱导肿瘤细胞或感染病毒细胞凋亡的作用。近年来越来越多的研究发现,颗粒酶B也可在细胞外基质中发挥作用,导致受损组织愈合不良。颗粒酶B可通过诱导炎症因子表达,破坏血管完整性,增加炎症细胞浸润,促进组织炎症反应,通过释放转化生长因子-β(TGF-β),活化白细胞介素(IL)-18,降解核心蛋白聚糖,促进组织纤维化。颗粒酶B在组织损伤修复中的作用日益引起重视,本文就颗粒酶B促进组织炎症反应和纤维化的机制作一综述。
Previous studies on granzyme B mainly focused on its role in inducing apoptosis of tumor cells or virus-infected cells.In recent years,more and more studies have found that granzyme B can also play a role in the extracellular matrix,leading to poor injury repair.Granzyme B promotes tissue inflammation by inducing the expression of inflammatory factors,destroying vascular integrity and increasing inflammatory cell infiltration,and promotes tissue fibrosis by releasing transforming growth factor-β(TGF-β),activating interleukin(IL)-18 and degrading decorin.The role of granzyme B in injury repair has attracted increasing attention.This article reviews the mechanism of granzyme B in promoting inflammation and fibrosis.
作者
王在强
金发光
傅恩清
Wang Zaiqiang;Jin Faguang;Fu Enqing(Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Air Force Medical University, Xi′an 710038, China)
出处
《中华损伤与修复杂志（电子版）》
CAS
2021年第4期349-352,共4页
Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)
基金
陕西省重点研发计划(2017ZDL-SF-14-6)。
关键词
颗粒酶类
炎症
纤维化
损伤修复
Granzymes
Inflammation
Fibrosis
Injury repair
