基于表观遗传调控免疫细胞极化的针刺神经抗炎机理探析

Anti-Inflammatory Mechanism of Acupuncture Based on Epigenetic Regulation of Polarization of Immune Cells

炎症是机体对损伤因子产生的防御反应,是人类日常生活中常见的病理反应之一。近年来,针刺被广泛地应用于多种炎性疾病的治疗中,针刺的抗炎效应也被国际社会兼收博采,但其具体机制尚未完全明确。多种炎性疾病的发生离不开免疫细胞极化,T细胞和单核/巨噬细胞在炎症过程中尤为重要。实验研究发现,针刺可调控自主神经、促进中枢神经递质释放和影响免疫细胞的表观遗传修饰,而表观遗传可调节免疫细胞极化的方向。此外,针刺可以调节神经内分泌轴,促进激素释放,有证据表明激素也与免疫细胞极化密切相关。本研究从针刺对自主神经、神经递质、神经内分泌轴和表观遗传的影响进行综述,提出针刺抗炎的神经免疫学调控新机制,以期为临床提供依据。

Inflammation is the defensive reaction of the body to the injury factors,which is one of the common pathological reactions in human daily life.Acupuncture is widely used in the treatment of a variety of inflammatory diseases,and its anti-inflammatory effect is widely accepted by the international community,but the specific mechanism is not completely clear.The occurrence of various inflammatory diseases is inseparable from immune cell polarization,and T cells and monocytes/macrophages are particularly important in the inflammatory process.Experimental studies have found that acupuncture can regulate autonomic nerve,promote the release of central neurotransmitter,and affect the epigenetic modification of immune cells,which can regulate the polarization direction of immune cells.In addition,acupuncture can regulate the neuroendocrine axis and promote the release of hormones,which have been shown to be closely related to the polarization of immune cells.This study reviewed the effects of acupuncture on autonomic nerve,neurotransmitter,neuroendocrine axis and epigenetics.The new neuroimmunological regulation mechanism of acupuncture in anti-inflammation is proposed in the study so as to provide clinical basis.