单核细胞血小板聚集体的研究进展

Research progress in monocyte-platelet aggregates

循环中单核细胞血小板聚集体(monocyte-platelet aggregates,MPA)是血小板活化和炎症反应的敏感且有力的标志,MPA是介于炎症与血栓形成的桥梁。血小板激活后与单核细胞上的P-选择素糖蛋白配体-1(P-selectin glycoprotein ligand-1,PSGL-1)结合,形成MPA,在促进血液高凝及血栓形成、参与炎症反应调节炎症过程、监测肿瘤病情等方面发挥重要作用。本文回顾近年来MPA相关文献,围绕MPA的形成,对其功能以及在疾病中的作用进行综述,为血栓栓塞及炎症相关疾病的治疗提供新的靶点。

Monocyte-platelet aggregates(MPA)in circulation is a sensitive and powerful sign of platelet activation and inflammatory response,and MPA is a bridge between inflammation and thrombosis.After activation,platelets bind to p-selectin glycoprotein ligand-1(PSGL-1)on monocytes to form MPA,which plays an important role in promoting blood hypercoagulation and thrombosis,participating in inflammatory response and regulating inflammatory process,and monitoring tumor disease.In this paper,we will review literatures about MPA in recent years,and focus on the formation of MPA,its function and progress in diseases,so as to provide new targets for the treatment of thromboembolism and inflammation-related diseases.