泛素特异性蛋白酶39的生物学功能及在肿瘤中的研究进展

Biological functions of ubiquitin-specific protease 39 and its research progress in tumors

泛素特异性蛋白酶39(ubiquitin-specific protease 39,USP39)是泛素特异性蛋白酶家族的成员之一,在多种肿瘤细胞中高表达。USP39不仅能够参与剪接体的形成,参与pre-mRNAs的剪接过程,在维持纺锤体的稳定、调节细胞周期方面也起着重要的作用。USP39可以通过多种信号通路调节细胞的增殖、迁移、细胞周期阻滞、增加肿瘤细胞对化疗药物和放射的耐受性,导致肿瘤的恶性进展等。本文就USP39的生物学功能及其在肿瘤发生发展中的作用进行综述,为基于USP39的肿瘤诊断和治疗提供理论依据。

USP39,a member of the ubiquitin-specific protease family,is highly expressed in a variety of tumor cells.USP39 is not only involved in the formation of spliceosome and the splicing process of many pre-mRNAs,but also plays an important role in maintaining the stability of spindles and regulating the cell cycle.Studies have shown that USP39 can regulate cell proliferation,migration,cell cycle arrest,and increase the tolerance of tumor cells to chemotherapy drugs and radiation through a variety of signaling pathways,leading to the malignant progression of tumors.This paper reviews the biological functions of USP39 and its role in the development of tumorigenesis.It provides theoretical basis for tumor diagnosis and treatment based on USP39.