经皮肾镜碎石术治疗上尿路结石的临床效果及对患者术后炎性反应的影响

Clinical Efficacy of Percutaneous Nephrolithotomy in the Treatment of Upper Urinary Calculi and Its Influence on Postoperative Inflammatory Response

目的:探究经皮肾镜碎石术(percutaneous nephrostolithotomy,PCNL)治疗上尿路结石对患者疗效及术后炎症反应的影响。方法:收集2016年6月-2019年6月在本院确诊收治的上尿路结石患者80例作为研究对象,随机将其分为PCNL组(P组,n=40)和传统输尿管切开取石术组(C组,n=40)。观察经皮肾镜组和传统切口组手术时间、清石率、住院时间,并对术前后血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平进行分析。结果:P组手术时间、术后住院时间均短于C组,而术后二次手术率及清石率均优于C组,差异均有统计学意义(P<0.05);术后第14天,P组CRP、IL-6及IL-8水平均低于C组,差异均有统计学意义(P<0.05)。结论:对于复杂性上尿路结石,PCNL术式具有高效的治疗效果,且可有效缓解术后炎性反应。

Objective:To explore the effect of percutaneous nephrolithotomy (PCNL) in the treatment of upper urinary tract calculi and the effect of postoperative inflammatory response.Method:From June 2016 to June 2019,80 patients with upper urinary calculi in our hospital were selected as the research objects.They were randomly divided into PCNL group (group P,n=40) and traditional ureterolithotomy group (group C,n=40).The operation time,stone removal rate and hospitalization time were observed in the percutaneous nephrolithotomy group and the traditional incision group,and the serum levels of C-reactive protein (CRP),interleukin-6 (IL-6) and interleukin-8 (IL-8) before and after operation were analyzed.Result:The operation time and postoperative hospital stay in group P were shorter than those in group C,while the secondary operation rate and stone removal rate were better than those in group C (P<0.05);on the 14 th day after operation,the levels of CRP,IL-6 and IL-8 in group P were lower than those in group C (P<0.05).Conclusion:PCNL is an effective treatment for complicated upper urinary tract calculi,and can effectively relieve postoperative inflammatory response.