自拟固齿散治疗慢性牙周炎临床疗效及对龈沟液IL-6、IL-1β、MMP-13的影响

Clinical Efficacy of Using Self-made Guchi Powder in the Treatment of Chronic Periodontitis and Its Influence on Gingival Crevicular Fluid IL-6,IL-1β and MMP-13

目的:观察自拟固齿散治疗胃火上蒸型慢性牙周炎临床疗效及对龈沟液白介素-6(IL-6)、白介素1-β(IL-1β)、基质金属蛋白酶-13(MMP-13)的影响。方法:选取2019年8月~2020年8月于我院收治的92例胃火上蒸型慢性牙周炎患者为研究对象,使用随机数字表法分为对照组(n=46)和观察组(n=46)。对照组患者予以牙周基础治疗,观察组患者在对照组基础上予以自拟固齿散治疗。比较两组患者治疗3个月后疗效差异,比较两组患者治疗前、治疗3个月后中医症候积分、牙周情况[牙周探诊深度(PD)、牙龈出血指数(BI)]、龈沟液免疫因子(IL-6、IL-1β、MMP-13)差异,比较两组患者治疗期间药物不良反应差异。结果:治疗3个月后,两组患者疗效差异显著,观察患者总有效率高于对照组(P均<0.05);两组患者中医症候积分得分、PD、BI、IL-6、IL-1β、MMP-13均较治疗前降低,且观察组低于同期对照组(P均<0.05),两组患者治疗期间药物不良反应差异不显著(P均>0.05)。结论:自拟固齿散治疗胃火上蒸型慢性牙周炎效果较好,可缓解患者中医症状,能有效改善患者牙周情况,降低IL-6、IL-1β、MMP-13水平,且安全性较好。

Objective: To explore the clinical efficacy of using Self-made Guchi Powder in the treatment of chronic periodontitis and its influence on gingival crevicular fluid interleukin-6(IL-6),interleukin 1-β(IL-1β) and matrix metalloproteinase-13(MMP-13). Methods: A total of 92 patients with stomach-heat upward steaming type chronic periodontitis who were admitted to our hospital from August 2019 to August 2020 were selected as the research subjects, and they were divided into a controlled group(n=46) and an observation group(n=46) by using the random number table method. Patients in the controlled group received basic periodontal treatment, and patients in the observation group received Self-made Guchi Powder on the basis of the controlled group. The efficacy of the two groups was compared after 3 months of treatment, and the TCM syndromes scores, periodontal status [periodontal probing depth(PD),gingival bleeding index(BI)] and gingival crevicular fluid immune factors(IL-6,IL-1β,MMP-13) were compared between the two groups before treatment and after 3 months of treatment. The differences in adverse drug reactions were compared between the two groups during treatment. Results: After 3 months of treatment, there was a significant difference in efficacy between the two groups of patients, and the total effective rate of the observation group was higher than that of the controlled group(all P<0.05). The scores of TCM syndromes and levels of PD,BI,IL-6,IL-1β and MMP-13 in the two groups were lower than those before treatment, and the scores and levels of the observation group were lower than those of the controlled group during the same period(all P<0.05). There were no significant differences in adverse drug reactions between the two groups during treatment(all P>0.05). Conclusion: Self-made Guchi Powder has a good effect in treating chronic periodontitis of stomach-heat upward steaming. And it can alleviate the TCM symptoms, effectively improve the periodontal status, and reduce the levels of IL-6,IL-1β and MMP-13,with good safety.