幽门螺杆菌与胃肠道微生态关系的研究进展

Advances in research on relationship between Helicobacter pylori and gastrointestinal microecology

幽门螺杆菌作为慢性胃炎、消化性溃疡和胃癌的病原体,大多在儿童期获得,并在成人期持续存在。早期诊断及治疗可有效减少幽门螺杆菌感染相关疾病及不良后果的发生,但儿童幽门螺杆菌感染根除率仍较低,其与幽门螺杆菌药物依从性差及抗生素耐药有关。而欧洲国家儿童幽门螺杆菌感染降低,但儿童早期哮喘、炎症性肠病、胃肠道感染及Barrett食管等疾病的发生率增高。了解胃肠道微生物组与幽门螺杆菌感染的相互作用可能为儿童幽门螺杆菌感染的诊疗及预防提供新的办法。本文就幽门螺杆菌与胃肠道菌群关系研究进展作一综述。

Helicobacter pylori(H.pylori) is a known pathogen in chronic gastritis, peptic ulcer, and gastric cancer, usually acquired in the early childhood and persists lifelong in adulthood without any therapy. Early diagnosis and treatment can effectively prevent H.pylori-related diseases and adverse consequences. However, the rate of successful eradication is lower in children due to poor drug compliance and the pathogen′s resistance to antibiotics. With the decline of the prevalence in children of European countries, the incidences of early-onset asthma, inflammatory bowel disease, gastro-intestinal and systemic infections and Barrett′s esophagus increased. An understanding of the interaction between gastrointestinal microbiome and H.pylori infection might provide novel targets for the prevention or treatment in children. This review aimed to elucidate the advances in researches on the relationship between Helicobacter pylori and gastrointestinal microbiome.