乌鲁木齐、伊犁两地区汉族心血管衰老规律差异与西北燥证相关性研究

Relationship between the difference of cardiovascular aging law and northwest dryness syndrome of Han nationality in Urumqi and Yili

目的:探讨乌鲁木齐、伊犁两地区汉族心血管衰老规律差异与西北燥证的相关性。方法:从乌鲁木齐、伊犁两地区筛选自我评价健康的汉族居民共计474例,采用现场调查、实验室检测、心脏彩超检查相结合的方法,比较两地区汉族心血管衰老规律差异与西北燥证的相关关系。结果:(1)乌鲁木齐地区汉族西北燥证罹患率23.25%(73/314)显著高于伊犁汉族14.38%(23/160)(P<0.05);(2)两地区汉族西北燥证罹患率除老年组外均随增龄升高:乌鲁木齐青年组10.9%、中年组22.5%、年轻老年组36.7%、老年组16.3%,伊犁青年组2.8%、中年组8.7%、年轻老年组23.3%、老年组22.9%,两地区4个年龄组间比较差异均有统计学意义(P<0.05);(3)乌鲁木齐、伊犁两地区汉族心血管衰老相关指标随增龄升高或下降,其中收缩压、脉压、脉压指数、尿素氮、胱抑素C、血浆白蛋白、升主动脉内径、左房前后径、肺动脉内径及左室射血分数在4个年龄组间比较差异均有统计学意义(P<0.05);(4)西北燥证总积分、肺卫孔窍皮肤燥证积分、肝肾精血不足证积分、肺心脾风火燥证积分、心肾阴虚证积分、脾胃阴虚证积分及总积分乌鲁木齐较伊犁为高,肺卫孔窍皮肤燥证积分两地区比较差异有统计学意义(P<0.05);(5)Pearson相关分析:乌鲁木齐汉族西北燥证总积分与脉压、肌酐、胱抑素C、左房前后径、左室舒张末期内径、左室收缩末期内径、左室射血分数存在相关性(|r|=0.204~0.531,P<0.05);伊犁汉族西北燥证总积分与脉压、左房前后径、左室舒张末期内径、左室收缩末期内径、右心室内径、肺动脉内径存在相关性(|r|=0.212~0.534,P<0.05,P<0.01)。结论:乌鲁木齐、伊犁两地区汉族心血管衰老规律与西北燥证存在相关关系,西北燥证是影响心血管衰老进展的因素之一。

Objective: To explore the relationship between the difference of cardiovascular aging law and northwest dryness syndrome of Han nationality in Urumqi and Yili. Methods: A total of 474 Han residents with self-evaluation of health were selected from Urumqi and Yili, using the methods of on-the-spot investigation, laboratory detection and cardiac color ultrasound examination. To compare the relationship between the difference of cardiovascular aging law of Han nationality and northwest dryness syndrome in the two areas. Results:(1)The attack rate of northwest dryness syndrome of Urumqi Han nationality(23.25%, 73/314) was higher than that of Yili Han nationality(14.38%, 23/160), and the difference was statistically significant(P<0.05).(2)The attack rate of northwest dryness syndrome of Han nationality in two areas increased with age(except for the elderly group): 10.9% in Urumqi youth group, 22.5% in middle-aged group, 36.7% in young and elderly group, 16.3% in old group, 2.8% in Yili youth group, 8.7% in middle-aged group, 23.3% in young and old group, and 22.9% in old group. There were significant differences between the four age groups in the two regions(P<0.05).(3)The related indexes of cardiovascular aging of Han nationality in Urumqi and Yili increased or decreased with age. There were significant differences in systolic blood pressure, pulse pressure, pulse pressure index, urea nitrogen, cystatin C, plasma albumin, ascending aorta diameter, left atrial anterior and posterior diameter, pulmonary artery diameter and left ventricular ejection fraction among the four age groups(P<0.05).(4)The total score of northwest dryness syndrome, the score of skin dryness syndrome of lung-defense hole orifice, the integral of deficiency of essence and blood of liver and kidney, the score of wind fire dryness syndrome of lung, heart and spleen, the integral of yin deficiency syndrome of heart and kidney and the integral of yin deficiency syndrome of spleen and stomach in Urumqi are higher than those in Yili. There is significant difference in the score of skin dryness syndrome between the two areas(P<0.05).(5)Pearson correlation analysis: the total score of northwest dryness syndrome in Urumqi Han nationality was correlated with pulse pressure, creatinine, cystatin C, left atrial anterior and posterior diameter, left ventricular end-diastolic diameter, left ventricular end-systolic diameter and left ventricular ejection fraction(|r|=0.204~0.531, P<0.05). The total score of northwest dryness syndrome in Yili Han nationality was correlated with pulse pressure, left atrial anterior and posterior diameter, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, right ventricular diameter and pulmonary artery diameter(|r|=0.212~0.534, P<0.05, P<0.01). Conclusion: There is a correlation between cardiovascular aging and northwest dryness syndrome of Han nationality in Urumqi and Yili. Northwest dryness syndrome is one of the factors affecting the progress of cardiovascular aging.