循环生物标志物在急性心肌梗死患者预后评估中的价值

Value of Circulating Biomarkers in Prognosis of Patients with Acute Myocardial Infarction

简单、快速获取的循环生物标志物对于评估急性心肌梗死(AMI)患者的预后至关重要。其主要包括炎症反应相关标志物(如中性粒细胞、淋巴细胞、C反应蛋白)、血栓状态相关标志物(如血小板计数、平均血小板体积)、氧化应激相关标志物(如胆红素)以及其他新型生化标志物(如血清丝氨酸蛋白酶、血浆肾素活性)。这些生物标志物大量存在于外周循环中,与AMI患者的预后密切相关,同时循环生物标志物性质稳定,易于检测,在AMI发生发展进程中起重要作用,有望成为AMI早期预警和患者预后评估的新型指标。

Simple and fast access to the circulating biomarkers is very important for evaluating the prognosis of acute myocardial infarction(AMI).It mainly include inflammatory reaction related markers(such as neutrophils,lymphocytes,C-reactive protein,etc.),thrombosis related markers(such as platelet count,mean platelet volume,etc.),oxidative stress related markers(such as bilirubin),and other new biochemical markers(such as serum serine protease,plasma renin activity,etc.).These biomarkers exist in peripheral circulation in great quantities,which are closely related to the prognosis of AMI patients,and they are featured with stable nature and easy detection,plyaing an important role in the onset and progress of AMI,therefore are expected to become the new indicators for the early warning and prognosis assessment of AMI.