肠道菌群失调在孤独症谱系障碍发生发展中作用和机制的研究进展

Research Advance in Role of Intestinal Dysbacteriosis in Pathogenesis and Mechanism of Autism Spectrum Disorder

孤独症谱系障碍(ASD)是一组神经发育障碍性疾病,其发病机制复杂,缺乏有效治疗药物,部分病例预后不良。肠道菌群失调在ASD的发生发展过程中具有重要作用,其内在机制极为复杂,涉及神经内分泌系统、神经免疫系统及迷走神经系统途径,这些途径之间既相互区别又存在密切联系。ASD患者上述3个方面均存在不同程度的缺陷,提示肠道菌群失调通过影响脑-肠-微生物轴导致ASD的发生发展。深入研究肠道菌群失调在ASD发生发展中的作用以及相关分子机制可为ASD的临床治疗和后续研究提供新思路。

Autism spectrum disorder(ASD)is a group of neurodevelopmental disorders.The pathogenesis of ASD is complex,lacking of effective drugs,and some cases have poor prognosis.Intestinal dysbacteriosis plays an important role in the occurrence and development of ASD.The internal mechanisms are extremely complex,involving neuroendocrine system,neuroimmune system and vagal nervous system pathways,which are different from each other but closely related.Patients with ASD have different degrees of defects in these aspects,suggesting that intestinal dysbacteriosis causes the occurrence and development of ASD by affecting the brain-gut-microbial axis.Further study on the role of intestinal dysbacteriosis in the occurrence and development of ASD and the related molecular mechanisms can provide new ideas for the clinical treatment and further researches of ASD.