摘要
目的分析血管内介入治疗对颅内微小破裂动脉瘤患者血清神经元特异性烯醇化酶(NSE)、S100B蛋白水平的影响。方法选择重庆医科大学附属第一医院2012年12月至2020年8月收治的62例颅内微小破裂动脉瘤患者,通过随机数字表法分为对照组和观察组,各31例。对照组患者采用开颅手术夹闭治疗,观察组患者采用血管内介入治疗,两组患者均于术后随访6个月。比较两组患者手术相关指标、动脉瘤闭塞程度及术后6个月预后情况,术前、术后1 d血清NSE、S100B蛋白水平,随访期间并发症发生情况。结果观察组患者手术时间、住院时间均显著短于对照组,手术费用显著高于对照组;观察组患者致密闭塞占比显著高于对照组;术后6个月,观察组患者格拉斯哥预后评分量表(GOS)评分显著高于对照组(均P<0.05);与术前比,两组患者术后1 d血清NSE、S100B蛋白水平显著升高,但组间比较,差异无统计学意义(P>0.05);随访期间观察组患者并发症总发生率显著低于对照组(P<0.05)。结论血管内介入治疗颅内微小破裂动脉瘤患者,可缩短其手术、住院时间,减少神经损伤,提高动脉瘤闭塞情况,安全有效,进而改善患者预后。
Objective To analyze the effects of endovascular interventional therapy on serum neuron-specific enolase(NSE)and S100B protein levels in patients with intracranial microruptured aneurysms.Methods A total of 62 patients with intracranial microrupture aneurysms admitted to the First Affiliated Hospital of Chongqing Medical University from December 2012 to August 2020 were selected and divided into the control group and the observation group by random number table method,with 31 cases in each group.Patients in the control group were treated with craniotomy and clipping,and patients in the observation group were treated with intravascular interventional therapy.Both groups were followed up for 6 months after surgery.The operation-related indicators,aneurysm occlusion degree and prognosis 6 months after operation,NSE and S100B levels before and 1 day after surgery,the complications occurred during the follow-up period were companid between the two groups.Results The operation time and hospital stay of the observation group were significantly shorter than those of the control group;the operation cost was significantly higher than that of the control group;the proportion of patients with dense occlusion in the observation group were significantly higher than that in the control group;6 months after the operation,the Glasgow Outcome Score(GOS)score of the observation group were significantly higher than that of the control group(all P<0.05);compared with before operation,the serum NSE and S100B protein levels in the two groups increased significantly 1 day after surgery,but there was no statistical significance between the two groups(P>0.05);During the follow-up period,the incidence of complications in the observation group were significantly lower than that in the control group(P<0.05).Conclusion Endovascular interventional therapy for patients with microruptured intracranial aneurysms can shorten operative time and hospital stay,reduce nerve damage,improve the occlusion of aneurysms,it is safe and effective,and then improve patient prognosis.
作者
马亚伟
朱继
MA Yawei;ZHU Ji(Department of Neurosurgery,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400042,China)
