热射病患者血清CRP、TNF-α、IL-6指标的检测及临床意义分析

Analysis of the Detection and Clinical Significance of Serum CRP,TNF-αand IL-6 in Patients with Heat Stroke

目的:分析热射病患者血清炎症因子C-反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子(TNF-α)指标的检测结果及临床意义。方法:回顾性选择某院收治的80例热射病患者纳入H组,另选择同期行健康体检的80例健康者纳入J组,检测并对比H组、J组患者及H组不同病情程度、预后组患者血清CRP、TNF-α、IL-6水平。结果:H组患者血清CRP、TNF-α、IL-6均高于J组(P<0.05);合并中枢神经系统病变组、凝血功能障碍组患者血清CRP、TNF-α、IL-6均高于未合并组(P<0.05),合并胃肠功能障碍组患者血清TNF-α均高于未合并组(P<0.05),预后死亡组患者血清TNF-α、IL-6均高于存活组(P<0.05)。结论:通过对患者血清CRP、TNF-α、IL-6指标的检测对热射病患者病情的诊断、病情评估及预后判断具有重要的意义。

Objective:To analyze the detection results and clinical significance of serum inflammatory factors C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α (TNF-α)in patients with heat stroke.Methods:80 patients with heat stroke in a hospital were retrospectively selected as group H,and another 80 healthy people who underwent physical examination in a hospital during the same period were selected as group J.The serum CRP,TNF-αand IL-6 levels of patients in group H,group J,group H with different degrees of illness and prognosis group were detected and compared.Results:The levels of CRP,TNF-αand IL-6 in group H were higher than those in group J(P<0.05).The levels of CRP,TNF-αand IL-6 in patients with central nervous system disease and coagulation dysfunction were higher than those in patients without central nervous system disease and coagulation dysfunction(P<0.05).The level of TNF-αin patients with gastrointestinal dysfunction was higher than that in patients without coagulation dysfunction(P<0.05).The levels of TNF-αand IL-6 in patients with prognosis death group were higher than those in patients with survival group(P<0.05).Conclusion:The detection of serum CRP,TNF-αand IL-6 is of great significance in the diagnosis,evaluation and prognosis of patients with heat stroke.