不同剂量氯吡格雷辅助治疗对不稳定型心绞痛(UAP)患者血小板相关指标的影响

Effects of Different Doses of Clopidogrel on Platelet Related Indexes in Patients with Unstable Angina Pectoris

目的:探讨不同剂量氯吡格雷辅助治疗方案对不稳定型心绞痛(UAP)患者血小板相关指标的影响。方法:将某院2017年9月~2020年1月期间收治的UAP患者100例,按照计算机分组法分为大剂量组(52例,口服氯吡格雷150mg/d和阿司匹林100mg/d)和小剂量组(48例,口服氯吡格雷75mg/d和阿司匹林100mg/d)。于治疗前、治疗3个月后,对比两组治疗效果、血小板相关指标以及不良反应发生率。结果:治疗后,两组患者治疗效果、血小板颗粒膜蛋白140(GMP-140)水平、二磷酸腺苷(ADP)诱导血小板聚集率及花生四烯酸(AA)诱导血小板聚集率比较均无统计学意义(P>0.05),但是大剂量组不良反应发生率高于小剂量组(P<0.05)。结论:两种不同剂量氯吡格雷辅助阿司匹林均能有效降低血小板相关指标,提高临床疗效,且治疗效果相似,但是小剂量治疗方案具有更低的不良反应发生率,安全性更高。

Objective:To investigate the effect of different doses of clopidogrel on platelet related indexes in patients with unstable angina pectoris(UAP).Methods:100 patients with UAP in a hospital from September 2017 to January 2020 were divided into high-dose group(52 cases,oral clopidogrel 150mg/D and aspirin 100mg/D)and low-dose group(48 cases,oral clopidogrel 75mg/D and aspirin 100mg/D).Before treatment and 3 months after treatment,the treatment effect,platelet related indicators and the incidence of adverse reactions were compared between the two groups.Results:After treatment,there was no significant difference in the treatment effect,GMP-140 level,ADP induced platelet aggregation rate and AA induced platelet aggregation rate between the two groups(P>0.05),but the incidence of adverse reactions in the high-dose group was higher than that in the low-dose group(P<0.05).Conclusion:Two different doses of clopidogrel combined with aspirin can effectively reduce platelet related indicators and improve the clinical efficacy,and the treatment effect is similar,but the low-dose treatment scheme has lower incidence of adverse reactions,with higher safety.