Expression and clinical value of circular RNA Hsa_circ_0046701 in gliomas

Objective:To explore the expression of hsa_circ_0046701 in patients with glioma and its correlation with clinicopathological features and prognosis of glioma,and to study its clinical value.Methods:qRT-PCR was used to detect the expression of hsa_circ_0046701 in glioma tissues and normal brain tissues,and chi-square test was used to analyze the effects of different levels of hsa_circ_0046701 expression on the clinicopathological features of patients.The survival curve was drawn by Kaplan-Meier method,and the univariate and multivariate analysis of prognosis was performed by Cox proportional hazard regression model.Results:The expression level of hsa_circ_0046701 in gliomas was significantly higher than that in normal brain tissues,and the expression in gradeⅢ-Ⅳgliomas was higher than that gradeⅠ-Ⅱgliomas in WHO grade.The expression of hsa_circ_0046701 was significantly correlated with WHO grade,KPS score and postoperative recurrence,but not with age,sex,tumor size,number and location.The five-year survival rate of the group with high expression of hsa_circ_0046701 was lower than that of the group with low expression of hsa_circ_0046701.The patients with high expression of hsa_circ_0046701,had high WHO grade and the KPS score was less than 80.Postoperative recurrence was an independent prognostic factor for glioma patients.Conclusion:Hsa_circ_0046701 is highly expressed in gliomas,which is positively correlated with the malignant degree of gliomas,and can be used as a potential biological marker.High expression of hsa_circ_0046701,high WHO grade,KPS score<80,postoperative recurrence are the key factors affecting the prognosis of patients,which can be used as independent prognostic factors for patients.