轻度地中海贫血孕妇伴有缺铁性贫血的诊断及治疗临床研究

Clinical Study on Diagnosis and Treatment of Mild Thalassemia Pregnant Women with Iron Deficiency Anemia

目的探讨轻度地贫孕妇伴有缺铁性贫血(IDA)的诊断及临床治疗。方法选取在本院产检的155例地贫合并IDA孕妇,根据随机对照原则分为两组,A组81例给予口服铁剂治疗,B组74例不给予补充铁剂治疗;选择同期门诊产检的75名健康孕妇作为C组,对比分析A、B、C三组的临床诊断结果以及A、B两组的治疗效果。结果治疗前C组的平均红细胞体积(MCV)(87.31±2.10)fL、平均红细胞血红蛋白含量(MCH)(30.47±1.52)pg、血红蛋白(Hb)(126.22±6.03)g/L、血清铁(SI)(21.12±3.29)μmol/L、铁蛋白(SF)(94.59±22.60)μg/L显著大于A组和B组,差异有统计学意义(P<0.05),C组的红细胞分布宽度(RDW)(13.05±0.68)%显著低于A组和B组,差异有统计学意义(P<0.05),治疗后A组的Hb(113.60±1.59)g/L、SI(16.57±0.80)μmol/L、SF(59.79±3.00)μg/L显著高于B组,差异有统计学意义(P<0.05)。结论轻度地贫伴有IDA孕妇通过血常规检查,辅助SI、SF检查,确定孕妇地贫伴发IDA的情况;轻度地贫伴有缺铁孕妇应及时接受补铁治疗,改善自身缺铁症状,提升Hb、SI、铁蛋白水平,通过足量的铁保证胎儿发育以及自身健康。

Objective To explore the diagnosis and clinical treatment of iron-deficiency anemia(IDA)in pregnant women with mild thalassemia.Methods Selected 155 cases of thalassaemia and IDA pregnant women in the hospital for obstetrics and were divided into two groups according to the principle of randomized control,81 cases of group A were given oral iron treatment,74 cases of group B were not given iron supplementation;75 cases of outpatient obstetrics during the same period were selected A healthy pregnant woman was taken as group C,and the clinical diagnosis results of groups A,B,and C and the treatment effects of groups A and B were compared and analyzed.Results Before treatment,the mean red blood cell volume(MCV)(87.31±2.10)fL,mean red blood cell hemoglobin content(MCH)(30.47±1.52)pg,hemoglobin(Hb)(126.22±6.03)g/L,serum iron(SI)of group C(21.12±3.29)/L,ferritin(SF)(94.59±22.60)/L were significantly larger than those of group A and group B,the difference was statistically significant(P<0.05),the red blood cell distribution width(RDW)of group C(13.05±0.68)%was significantly lower than that of group A and group B,and the difference was statistically significant(P<0.05).After treatment,group A's Hb(113.60±1.59)g/L,SI(16.57±0.80)/L,SF(59.79±3.00)/L was significantly higher than that of group B,and the difference was statistically significant(P<0.05).Conclusion Through blood routine examination,serum ferritin and ferritin examination,we can determine the situation of IDA in pregnant women with mild thalassemia;Pregnant women with mild thalassemia and iron deficiency should receive iron supplement treatment in time to improve their own iron deficiency symptoms,improve hemoglobin,serum iron and ferritin levels,and ensure fetal development and their own health through sufficient iron.