基于数据挖掘技术探讨中药治疗冠心病伴焦虑抑郁的用药规律

Medication Regularity of Traditional Chinese Medicine in the Treatment of Coronary Heart Disease with Anxiety and Depression Based on Data Mining

目的运用数据挖掘技术探讨中药治疗冠心病伴焦虑抑郁的用药规律,为临床治疗提供参考。方法通过检索中国知识资源总库(CNKI),从建库至2020年5月30日中药治疗冠心病伴焦虑抑郁的相关文献,建立中药处方数据库,运用SPSS 20.0、SPSS Modeler 18.0软件进行分析,探究用药规律。结果共纳入80篇文献,处方80个,使用频次居前10位的中药为甘草、柴胡、丹参、白芍、当归、川芎、郁金、茯苓、半夏、酸枣仁等;关联分析显示治疗冠心病伴焦虑抑郁排名前4位的配伍药物为柴胡-枳壳、柴胡-郁金-白芍、柴胡-川芎-白芍、柴胡-川芎-白芍-甘草;聚类分析发现治疗冠心病伴焦虑抑郁的中药分为3类,包括健脾安神补中益气、养血活血理气化痰、疏肝解郁类。结论数据挖掘研究为冠心病伴焦虑抑郁的临床治疗和中药组方开发提供了参考依据;冠心病伴焦虑抑郁病机为本虚标实,本虚多为气虚,标实以气滞、血瘀、痰湿为主;治疗应把握益气养阴、养血活血、行气化痰、解郁安神等方法,结合病人实际情况辨证论治。

Objective To explore medication regularity of traditional Chinese medicine in the treatment of coronary heart disease with anxiety and depression based on data mining,so as to provide reference for clinical treatment.Methods By screening China Journal Full-Text Database(CNKI)from establishment to May 30,2020,literatures in the treatment of coronary heart disease with anxiety and depression by traditional Chinese medicine were collected.Traditional Chinese medicine prescription database was analyzed by SPSS 20.0 and SPSS Modeler 18.0 software to explore the medication regularity.Results A total of 80 literatures were screened,involving 80 prescriptions.The most frequently used traditional Chinese medicines were Liquorice,Bupleurum,Salvia miltiorrhiza,Radix Paeoniae,Angelica sinensis,Ligusticum,Chuanxiong,Turmeric,Poria,Pinellia tuber,Zizyphus jujube seed.The correlation analysis showed that the top 4 compatible drugs in the treatment of coronary heart disease with anxiety and depression were Bupleurum-Fructus aurantii immaturus,Bupleurum-Ligusticum-Radix Paeoniae,Bupleurum-Chuanxiong-Radix Paeoniae,and Bupleurum-Ligusticum Chuanxiong-Radix Paeoniae-Liquorice.The cluster analysis showed that the traditional Chinese medicine in the treatment of coronary heart disease with anxiety and depression could be divided into three categories,including invigorating spleen,tranquilizing spirit and replenishing body and replenishing qi,nourishing blood,activating blood,regulating qi and resolving phlegm,dredging liver and relieving depression.Conclusion The data mining provided some reference in the treatment of coronary heart disease with anxiety and depression and the development of traditional Chinese medicine prescriptions.The results suggested that pathogenesis of coronary heart disease with anxiety and depression was the basic deficiency and the normal deficiency.The basic deficiency was mostly Qi deficiency,and the standard deficiency was mainly Qi stagnation,blood stasis and phlegm dampness.Treatment should be based on the methods of nourishing qi and nourishing Yin,nourishing blood and promoting blood circulation,resulving phlegm by clearing damp,relieving depression and calming nerves,and dialectical treatment should be carried out according to the actual situation of the patient.