天津地区初治艾滋病患者高脂血症发生率及其高危因素的研究

A study of the prevalence and risk factors of hyperlipemia among Tianjin antiretroviral-naive AIDS patients

目的:了解天津地区初治艾滋病(AIDS)患者高脂血症的发生率及高危因素。方法:收集天津地区2019年初治AIDS患者737例,采用横断面的研究方案探讨初治AIDS患者高脂血症的发生率,对其影响因素进行单因素分析。结果:2019年天津地区737例初治AIDS患者中,甘油三酯中位水平1.2(0.37~8.09)mmol/L,胆固醇(4.05±0.85)mmol/L,高胆固醇血症的发生率为9.77%(72/737),高甘油三酯血症发生率为12.21%(90/737),高血糖发生率为11.40%(84/737)。年龄≥40岁、超重、高血糖水平是初治AIDS患者发生高脂血症的高危因素,而AIDS感染本身与高脂血症无相关性。结论:初治AIDS患者中,高脂血症的发生率不低,年龄、超重及高血糖是发生高脂血症的高危因素,需引起感染科医师的高度重视。

Objective:To understand the incidence of hyperlipidemia and its high-risk factors in newly treated acquired immunodeficiency syndrome(AIDS)patients in Tianjin.Methods:All AIDS patients were screened at Tianjin in 2019.A cross-sectional study was conducted to prevalence of hyperlipemia,and the influence factors were analyzed by single factor analysis.Results:Among 737 AIDS patients,the median level of triglycerides is 1.2(0.37~8.09)mmol/L,cholesterol is(4.05±0.85)mmol/L,the incidence of hypercholesterolemia was 9.77%(72/737),the incidence of hypertriglyceridemia was 12.21%(90/737),and the incidence of hyperglycemia was 11.40%(84/737).Age elder than 40 years,obesity and hyperglycemia were the risk factors associated with hyperlipemia.However AIDS infection itself was not the risk factor of hyperlipemia.Conclusion:Among antiretroviral naive AIDS patients,the prevalence of hyperlipemia is not low.Age,obesity and hyperglycemia are the risk factors of hyperlipemia,which should be paid more attention by infectious physicians.