435例儿童腹型过敏性紫癜的中医证素分布特征分析

Distribution Characteristics of TCM Syndromes in 435 Children with HSP

目的:分析儿童腹型过敏性紫癜(henoch-schonlein purpura,HSP)的中医证素特征和分布规律。方法:按照儿童腹型HSP的疾病特征和流行病学调查规范,制作《儿童腹型过敏性紫癜临床调查表》,采集腹型HSP患儿的发病信息,共纳入435例,创建证素分析数据库,以因子分析方法分析儿童腹型HSP的中医证素。结果:通过因子分析法得出6个公因子:F1(气滞证素)、F2(血瘀证素)、F3(阳虚证素)、F4(阴虚证素)、F5(湿热证素)、F6(血虚证素)。上述6个证素的出现比例依次是:血瘀(238例,54.71%)>气滞(202例,46.44%)>湿热(185例,42.53%)>阴虚(149例,34.25%)>血虚(104例,23.91%)>阳虚(67例,15.40%)。1个证素单独出现107例,占24.60%;2个证素同时出现279例,占64.14%;3个证素同时出现91例,占20.92%;4个证素同时出现7例,占1.61%。结论:儿童腹型HSP的中医证素主要是血瘀、气滞、湿热;证素相兼以2个证素同时出现最多,以血瘀+气滞组合出现频次最高。

Objective:To analyze the characteristics and distribution laws of TCM syndromes in children with HSP.Methods:According to the characteristics and epidemiological investigation standard of HSP in children,Clinical Questionnaire of HSP in Children was made to collect the information of HSP children,and include 435 children,establish the database of syndrome elements analysis,factor analysis was used to survey TCM syndrome elements of children HSP.Results:Six common factors were obtained by factor analysis:F1(Qi stagnation syndrome element),F2(blood stasis syndrome element),F3(Yang deficiency syndrome element),F4(Yin deficiency syndrome element),F5(damp heat syndrome element)and F6(blood deficiency syndrome element),the proportions of the above six syndrome elements were as follows:blood stasis(238 cases,54.71%)>Qi stagnation(202 cases,46.44%)>damp heat(185 cases,42.53%)>Yin deficiency(149 cases,34.25%)>blood deficiency(104 cases,23.91%)>Yang deficiency(67 cases,15.40%).One syndrome element appeared alone in 107 cases and it held 24.60%;two syndrome elements appeared concurrently in 279 cases and it occupied 64.14%;three syndrome elements appeared simultaneously in 91 cases and 20.92%;four syndrome elements showed at the same time in seven cases,and it reached 1.61%.Conclusion:Syndrome elements of HSP in children are blood stasis,Qi stagnation and damp heat;two syndrome elements appearing simultaneously are the most,blood stasis+qi stagnation of the highest frequency.