柴石解毒颗粒治疗登革热临床观察

Clinical Observation on Chaishi Jiedu Granule in Treating Dengue Fever

目的:评价柴石解毒颗粒治疗登革热的临床疗效和安全性。方法:将登革热患者100例按随机数字表法分为两组各50例,试验组为柴石解毒颗粒联合常规治疗;对照组为常规治疗。结果:与对照组相比,治疗后试验组患者在发热、头痛、全身痛、腹泻、皮疹等症状体征复常时间具有优势(P<0.05);试验组患者治疗后白细胞计数、血小板计数高于对照组,差异有统计学意义(P<0.05);治疗后谷丙转氨酶、谷草转氨酶、乳酸脱氢酶两组比较差异无统计学意义(P>0.05)。不良反应发生率试验组低于对照组,差异具有统计学意义(P=0.013)。结论:柴石解毒颗粒在缓解患者发热、头痛、全身痛、腹泻、皮疹等方面与常规治疗相比有较好疗效,无明显不良反应。

Objective:To assess clinical effects and the safety of Chaishi Jiedu granules in treating dengue fever.Methods:All 100 patients suffering dengue fever were allocated to two groups according to random number table method,50 cases in each group,the experiment group accepted Chaishi Jiedu granules combined with conventional therapy;and the control group conventional therapy.Results:Compared with the control group,the experiment group showed the advantages in the recovery time of the symptoms and body signs including fever,headache,pantalgia,diarrhea,rash and others after treating(P<0.05);the experiment group was better than the control group in WBC count and platelet count increase after treating,and the difference had statistical meaning(P<0.05);the difference had no statistical meaning in alanine aminotransferase,aspartate aminotransferase and lactate dehydrogenase between both groups after treating(P>0.05).The experiment group was lower than the control group in the incidence of adverse reaction,and the difference had statistical meaning(P=0.013).Conclusion:Chaishi Jiedu granules own better clinical effects in relieving fever,headache,pantalgia,diarrhea,rash and others compared with the effects of conventional therapy without obvious adverse reaction.