核转录因子I-C在牙根发育中的作用

Role of Nuclear Factor I-C in Tooth Root Development

牙根发育是一个复杂的过程,由上皮和间充质共同调控完成,并涉及多种分子的相互作用。研究发现,核转录因子I-C(nuclear factor I-C,NFIC)是调控牙根发育的主要分子之一,NFIC参与根部牙本质的形成。牙根的生长是通过与多种分子相互作用实现的,这些分子包括转化生长因子-β(transforming growth factorβ,TGF-β)、Krüppel样转录因子4(Krüppel-like factor 4,KLF4)、Osterix(OSX)、Hedgehog(HH)、AFF4和微量元素锌等。本文将对NFIC在牙根形成过程中的作用和与NFIC相关的分子作一综述。

Tooth root development is a complex process,which is jointly controlled by epithelium and mesenchyme and involves the interaction of multiple molecules.The study found that nuclear transcription factor I-C(NFIC)is one of the main molecules that regulate tooth root development.NFIC is involved in the formation of root dentin and root growth through interaction with various molecules including transforming growth factorβ(TGFβ),Krüppel-like factor 4(KLF4),osterix(OSX),hedgehog(HH),AFF4,and trace element zinc.This article will review the role of NFIC in tooth root formation and the molecules related to NFIC.