超脉冲点阵CO_(2)激光联合自体脂肪移植治疗痤疮萎缩性瘢痕

The Therapeutic Effect of Super-pulsed Fractional CO_(2) Laser Combined with Autologous Fat Transplantation on Acne Atrophic Scar

目的:分析超脉冲点阵CO_(2)激光联合自体脂肪移植对痤疮萎缩性瘢痕的治疗作用。方法:按照随机数字表法将2019年10月-2020年10月笔者医院收治的86例痤疮萎缩性瘢痕患者分为对照组与观察组,每组43例。对照组采用超脉冲点阵CO_(2)激光进行治疗,观察组采用超脉冲点阵CO_(2)激光联合自体脂肪移植进行治疗。治疗1周后,观察两组治疗效果、结痂时间、结痂脱落时间、愈合时间、皮肤生理指标[经皮水分丢失(Transepidermal waterloss,TEWL)、红斑指数(Erythema index,EI)、角质层含水量]及不良反应情况。结果:观察组的总有效率明显高于对照组[95.35%(41/43) vs 76.74%(33/43)],差异有统计学意义(P<0.05)。观察组结痂时间、结痂脱落时间及愈合时间均明显短于对照组,差异有统计学意义(P<0.05)。观察组的TEWL、EI明显低于对照组,角质层含水量明显高于对照组,差异有统计学意义(P<0.05)。两组均未发生严重不良反应。结论:超脉冲点阵CO_(2)激光联合自体脂肪移植对痤疮萎缩性瘢痕具有很好的治疗作用,能够明显改善皮肤功能。

Objective To discuss the therapeutic effect of super-pulsed fractional CO_(2) laser combined with autologous fat transplantation on acne atrophic scar.Methods According to the random number table methods,86 patients with acne atrophic scar who was divided into the control group and the observation group in our hospital from October 2019 to October 2020,with 43 patients in each group.Patients were treated with super-pulsed fractional CO_(2) laser in the control group,while patients were treated with super-pulsed fractional CO_(2) laser combined with autologous fat transplantation in the observation group.One week after treatment,the therapeutic effect,scab time,scab shedding time,healing time,skin physiological indicators[transepidermal waterloss(TEWL),erythema index(EI),cuticle water content]and adverse reactions were observed in both groups.Results The total effective ratein the observation group was significantly higher than that in the control group[95.35%(41/43)vs 76.74%(33/43)],the difference was statistically significant(P<0.05).The scab time,scab shedding time and healing time in the observation group were significantly shorter than those in the control group(P<0.05).The TEWL and EI in the observation group were significantly lower than those in the control group(P<0.05),and the cuticle water content was significantly higher than that in the control group(P<0.05).There were no severe adverse reactions in both groups.Conclusion The super-pulsed fractional CO_(2) laser combined with autologous fat transplantation had a good therapeutic effect on acne atrophic scar,and it could significantly improve the skin function.