老年寻常型银屑病患者外周血PGE_(2)、ApoM、Hcy水平变化及与心理健康状态相关性分析

Changes of Peripheral Blood PGE_(2),ApoM,Hcy Levels in Elderly Patients with Psoriasis Vulgaris and Their Correlation with Mental Health State

目的:探究老年寻常型银屑病患者外周血前列腺素E_(2)(PGE_(2))、载脂蛋白M(ApoM)、同型半胱氨酸(Hcy)水平变化及与心理健康状态相关性。方法:选取笔者医院2019年12月-2020年6月老年寻常型银屑病患者106例作为研究对象,比较不同病情患者外周血PGE_(2)、ApoM、Hcy水平,根据一般健康量表(CHQ-12)评分分为伴心理障碍组与不伴心理障碍组,比较不同心理健康状态患者外周血PGE_(2)、ApoM、Hcy水平,分析各指标与CHQ-12评分相关性,并采用多元线性逐步回归分析外周血指标与心理状态的关系。结果:活动期患者外周血PGE_(2)、Hcy水平高于静止期,ApoM低于静止期,差异有统计学意义(P<0.05);外周血PGE_(2)、Hcy水平随皮损严重程度增加呈升高趋势,ApoM随皮损严重程度呈降低趋势(P<0.05)。Spearman相关性分析,外周血PGE_(2)、Hcy与疾病分期、皮损严重程度呈正相关(P<0.05);ApoM与疾病分期、皮损严重程度呈负相关(P<0.05)。伴心理障碍组与不伴心理障碍组外周血ApoM水平相比,差异无统计学意义(P>0.05);伴心理障碍组外周血PGE_(2)、Hcy水平高于不伴心理障碍组(P<0.05)。Pearson相关性分析,外周血PGE_(2)(r=0.767)、Hcy(r=0.593)与CHQ-12评分呈正相关(P<0.05);外周血ApoM(r=0.142)与CHQ-12评分无明显相关性(P>0.05)。多元线性逐步回归分析,将病程、疾病分期、皮损严重程度等其他因素控制后,外周血PGE_(2)、Hcy仍与心理健康状态显著相关(P<0.05)。结论:老年寻常型银屑病患者外周血PGE_(2)、ApoM、Hcy与病情密切相关,且PGE_(2)、Hcy水平与患者心理健康状态显著相关,临床需给予重视。

Objective To explore the changes in peripheral blood prostaglandin E_(2)(PGE_(2)),apolipoprotein M(ApoM)and homocysteine(Hcy)levels in elderly patients with psoriasis vulgaris and their correlation with mental health state.Methods A total of 106 elderly patients with psoriasis vulgaris from December 2019 to June 2020 in our hospital were selected as the research subjects.Compared the levels of PGE_(2),ApoM,and Hcy in the peripheral blood of patients with different conditions,and dividing them into groups with and without psychological disorders according to the Chinese health questionnaire(CHQ-12)score of the observation group.Analyzed the correlation between each index and CHQ-12 score,and used multiple linear stepwise regression to analyze the relationship between peripheral blood index and mental state.Results The levels of PGE_(2) and Hcy in active phase were higher than those in quiescent phase,and ApoM was lower than that in quiescent phase,the differences were statistically significant(P<0.05).The levels of PGE_(2) and Hcy in peripheral blood showed an increasing trend with the severity of skin lesions,and ApoM showed a decreasing trend with the severity of skin lesions(P<0.05).Spearman correlation analysis showed that PGE_(2) and Hcy in peripheral blood were positively correlated with disease stage and the severity of skin lesions(P<0.05).ApoM was negatively correlated with disease stage and the severity of skin lesions(P<0.05).There was no statistically significant difference in peripheral blood ApoM levels between the group with psychological disorders and the group without psychological disorders(P>0.05).The peripheral blood PGE_(2) and Hcy levels in the group with psychological disorders were higher than those without psychological disorders(P<0.05).Pearson correlation analysis showed that PGE_(2)(r=0.767)and Hcy(r=0.593)in peripheral blood were positively correlated with CHQ-12 score(P<0.05).Peripheral blood ApoM(r=0.142)was not significantly correlated with CHQ-12 score(P>0.05).Multivariate linear stepwise regression analysis,after controlling other factors such as disease course,disease stage,and severity of skin lesions,peripheral blood PGE_(2) and Hcy were still significantly correlated with mental health status(P<0.05).Conclusion Peripheral blood PGE_(2),ApoM,and Hcy of elderly patients with psoriasis vulgaris are closely related to the condition,and the levels of PGE_(2) and Hcy are significantly related to the mental health state of patients,and clinical attention should be paid.