奥曲肽联合普萘洛尔治疗肝硬化并发上消化道出血的疗效观察

Octreotide Combined with Propranolol in the Treatment of Cirrhosis Complicated with upper Gastrointestinal Bleeding

目的探究奥曲肽联合普萘洛尔治疗肝硬化并上消化道出血的疗效。方法在2017年6至2019年6月,选取我院收治的68例肝硬化并发上消化道出血的患者作为本次研究的试验组,给予奥曲肽联合普萘洛尔治疗;并同期选取68例肝硬化并发上消化道出血的患者作为本次研究的对照组,给予奥曲肽治疗,对比两组治疗效果。结果在治疗总有效率对比中,试验组(94.12%)显著高于对照组(79.41%),差异有统计学意义,P <0.05。在平均止血时间与出血复发率比较中,试验组显著优于对照组,差异有统计学意义,P <0.05。试验组患者出现面色苍白2例,胃胀气2例,呕吐2例,不良反应率为8.82%;对照组出现面色苍白6例,胃胀气4例,呕吐6例,腹泻2例,不良反应率为26.47%;对比差异有统计学意义,P <0.05。结论在肝硬化并发上消化道出血患者中给予奥曲肽联合普萘洛尔治疗,其治疗效果比较理想,能够显著改善患者症状,不良反应少,具有较高的安全性与有效性,显著改善患者出血症状,在临床上的应用价值较高。

Objective To explore the efficacy of octreotide combined with propranolol in the treatment of cirrhosis with upper gastrointestinal bleeding.Methods From June 2017 to June 2019,68 cases of liver cirrhosis complicated with upper gastrointestinal bleeding in our hospital were selected as the experimental group in this study,and octreotide combined with propranolol was given as treatment.Meanwhile,68 cases of liver cirrhosis complicated with upper gastrointestinal bleeding were selected as the control group in this study,and octreotide was given to compare the therapeutic effects of the two groups.Results In the comparison of the total effective rate of treatment,the experimental group(94.12%)was significantly higher than the control group(79.41%),and the difference was statistically significant(P<0.05).The experimental group was significantly better than the control group in average hemostatic time and recurrence rate of bleeding,with statistically significant difference(P<0.05).The experimental group had pale complexion in 2 case,flatulence in2 case,vomiting in 2 case,and the adverse reaction rate was 8.82%.In the control group,there were 6 cases of pale complexion,4 cases of flatulence,6 cases of vomiting and 2 case of diarrhea,and the adverse reaction rate was 26.47%.The difference was statistically significant,P<0.05.Conclusion Octreotide combined with propranolol can significantly improve the symptoms of patients with cirrhosis complicated with upper gastrointestinal bleeding,and has a relatively ideal therapeutic effect,with less adverse reactions,higher safety and effectiveness,and significantly improved bleeding symptoms of patients.Therefore,it is of high clinical application value.